1mwj
From Proteopedia
(Difference between revisions)
| (6 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:1mwj.png|left|200px]] | ||
| - | + | ==Crystal Structure of a MUG-DNA pseudo substrate complex== | |
| - | + | <StructureSection load='1mwj' size='340' side='right'caption='[[1mwj]], [[Resolution|resolution]] 2.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1mwj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MWJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mwj OCA], [https://pdbe.org/1mwj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mwj RCSB], [https://www.ebi.ac.uk/pdbsum/1mwj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mwj ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1mwj]] is a 2 chain structure with sequence from [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/MUG_ECOLI MUG_ECOLI] Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.<ref>PMID:8878487</ref> <ref>PMID:12668677</ref> | |
| - | == | + | == Evolutionary Conservation == |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | == | + | <jmolCheckbox> |
| - | <ref | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mw/1mwj_consurf.spt"</scriptWhenChecked> |
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mwj ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Barrett | + | [[Category: Large Structures]] |
| - | [[Category: Brown | + | [[Category: Barrett TE]] |
| - | [[Category: Jiricny | + | [[Category: Brown T]] |
| - | [[Category: Pearl | + | [[Category: Jiricny J]] |
| - | [[Category: Savva | + | [[Category: Pearl LH]] |
| - | [[Category: Scharer | + | [[Category: Savva R]] |
| - | [[Category: Verdine | + | [[Category: Scharer O]] |
| - | + | [[Category: Verdine GL]] | |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal Structure of a MUG-DNA pseudo substrate complex
| |||||||||||
Categories: Escherichia coli | Large Structures | Barrett TE | Brown T | Jiricny J | Pearl LH | Savva R | Scharer O | Verdine GL
