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1n8f

From Proteopedia

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[[Image:1n8f.png|left|200px]]
 
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{{STRUCTURE_1n8f| PDB=1n8f | SCENE= }}
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==Crystal structure of E24Q mutant of phenylalanine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHP synthase) from Escherichia Coli in complex with Mn2+ and PEP==
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<StructureSection load='1n8f' size='340' side='right'caption='[[1n8f]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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===Crystal structure of E24Q mutant of phenylalanine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHP synthase) from Escherichia Coli in complex with Mn2+ and PEP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1n8f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N8F FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12667068}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEP:PHOSPHOENOLPYRUVATE'>PEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8f OCA], [https://pdbe.org/1n8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n8f RCSB], [https://www.ebi.ac.uk/pdbsum/1n8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n8f ProSAT]</span></td></tr>
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[[1n8f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8F OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AROG_ECOLI AROG_ECOLI] Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n8/1n8f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n8f ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Aldolase|Aldolase]]
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*[[DAHP synthase 3D structures|DAHP synthase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:012667068</ref><references group="xtra"/>
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[[Category: 3-deoxy-7-phosphoheptulonate synthase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Bauerle, R.]]
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[[Category: Large Structures]]
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[[Category: Kretsinger, R H.]]
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[[Category: Bauerle R]]
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[[Category: Shumilin, I A.]]
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[[Category: Kretsinger RH]]
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[[Category: Metal binding protein]]
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[[Category: Shumilin IA]]

Current revision

Crystal structure of E24Q mutant of phenylalanine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHP synthase) from Escherichia Coli in complex with Mn2+ and PEP

PDB ID 1n8f

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