4ea3

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[[Image:4ea3.png|left|200px]]
 
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{{STRUCTURE_4ea3| PDB=4ea3 | SCENE= }}
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==Structure of the N/OFQ Opioid Receptor in Complex with a Peptide Mimetic==
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<StructureSection load='4ea3' size='340' side='right'caption='[[4ea3]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
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===Structure of the N/OFQ Opioid Receptor in Complex with a Peptide Mimetic===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ea3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EA3 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22596163}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.013&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0NN:1-BENZYL-N-[3-(1H,3H-SPIRO[2-BENZOFURAN-1,4-PIPERIDIN]-1-YL)PROPYL]-D-PROLINAMIDE'>0NN</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLB:(2S)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLB</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ea3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ea3 OCA], [https://pdbe.org/4ea3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ea3 RCSB], [https://www.ebi.ac.uk/pdbsum/4ea3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ea3 ProSAT]</span></td></tr>
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[[4ea3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EA3 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/OPRX_HUMAN OPRX_HUMAN] G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.<ref>PMID:11238602</ref> <ref>PMID:12568343</ref> <ref>PMID:22596163</ref> <ref>PMID:23086955</ref> <ref>PMID:8137918</ref>
==See Also==
==See Also==
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*[[G protein-coupled receptor|G protein-coupled receptor]]
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*[[Opioid receptor|Opioid receptor]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022596163</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Calo, G.]]
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[[Category: Large Structures]]
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[[Category: Cherezov, V.]]
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[[Category: Calo G]]
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[[Category: Chun, E.]]
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[[Category: Cherezov V]]
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[[Category: GPCR, GPCR Network.]]
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[[Category: Chun E]]
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[[Category: Guerrini, R.]]
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[[Category: Guerrini R]]
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[[Category: Huang, X P.]]
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[[Category: Huang XP]]
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[[Category: Katritch, V.]]
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[[Category: Katritch V]]
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[[Category: Liu, W.]]
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[[Category: Liu W]]
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[[Category: Roth, B L.]]
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[[Category: Roth BL]]
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[[Category: Stevens, R C.]]
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[[Category: Stevens RC]]
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[[Category: Thompson, A A.]]
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[[Category: Thompson AA]]
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[[Category: Trapella, C.]]
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[[Category: Trapella C]]
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[[Category: Vardy, E.]]
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[[Category: Vardy E]]
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[[Category: Wu, H.]]
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[[Category: Wu H]]
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[[Category: Fusion]]
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[[Category: Gpcr membrane protein 7tm nop orl1 cytochrome b562]]
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[[Category: Membrane transmembrane]]
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[[Category: Nociceptin orphanin fq compound 24 opioid]]
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[[Category: Psi-biology gpcr network]]
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[[Category: Receptor]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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Current revision

Structure of the N/OFQ Opioid Receptor in Complex with a Peptide Mimetic

PDB ID 4ea3

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