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3p3f
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| - | [[Image:3p3f.png|left|200px]] | ||
| - | + | ==Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK== | |
| - | + | <StructureSection load='3p3f' size='340' side='right'caption='[[3p3f]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3p3f]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P3F FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p3f OCA], [https://pdbe.org/3p3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p3f RCSB], [https://www.ebi.ac.uk/pdbsum/3p3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p3f ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[3p3f]] is a 6 chain structure with sequence from [ | + | == Function == |
| + | [https://www.uniprot.org/uniprot/FLK_STRCT FLK_STRCT] Hydrolyzes fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance. Can not use acetyl-CoA as substrate.<ref>PMID:16720268</ref> <ref>PMID:20836570</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Thioesterase|Thioesterase]] | + | *[[Thioesterase 3D structures|Thioesterase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Streptomyces cattleya]] | [[Category: Streptomyces cattleya]] | ||
| - | [[Category: Chang | + | [[Category: Chang MCY]] |
| - | [[Category: Coyle | + | [[Category: Coyle SM]] |
| - | [[Category: Doudna | + | [[Category: Doudna JA]] |
| - | [[Category: Jinek | + | [[Category: Jinek M]] |
| - | [[Category: Weeks | + | [[Category: Weeks AM]] |
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Current revision
Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK
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