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1sfe

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[[Image:1sfe.png|left|200px]]
 
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{{STRUCTURE_1sfe| PDB=1sfe | SCENE= }}
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==ADA O6-METHYLGUANINE-DNA METHYLTRANSFERASE FROM ESCHERICHIA COLI==
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<StructureSection load='1sfe' size='340' side='right'caption='[[1sfe]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===ADA O6-METHYLGUANINE-DNA METHYLTRANSFERASE FROM ESCHERICHIA COLI===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1sfe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_B Escherichia coli B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SFE FirstGlance]. <br>
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{{ABSTRACT_PUBMED_8156986}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sfe OCA], [https://pdbe.org/1sfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sfe RCSB], [https://www.ebi.ac.uk/pdbsum/1sfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sfe ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1sfe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SFE OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/ADA_ECOLI ADA_ECOLI] Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs O6-methylguanine and 04-methylthymine residues in alkylated DNA by a direct and irreversible transfer of the methyl group from the base to one of its own cysteine residues (Cys-321). Also specifically repairs the Sp diastereomer of DNA methylphosphotriester lesions by the same mechanism, although the methyl transfer occurs onto a different cysteine residue (Cys-38). Can not demethylate the other diastereomer, Rp-methylphosphotriester.<ref>PMID:2987862</ref> The methylation of Ada by methylphosphotriesters in DNA leads to its activation as a transcriptional regulator that activates the transcription of its own gene, ada, and other alkylation resistance genes, alkA, alkB and aidB.<ref>PMID:2987862</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sf/1sfe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sfe ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA methyltransferase|DNA methyltransferase]]
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*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:008156986</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/>
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__TOC__
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[[Category: Escherichia coli]]
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</StructureSection>
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[[Category: Demple, B.]]
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[[Category: Escherichia coli B]]
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[[Category: Dodson, E J.]]
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[[Category: Large Structures]]
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[[Category: Gulbis, J M.]]
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[[Category: Demple B]]
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[[Category: Moody, P C.E.]]
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[[Category: Dodson EJ]]
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[[Category: Moore, M H.]]
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[[Category: Gulbis JM]]
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[[Category: Dna repair protein]]
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[[Category: Moody PCE]]
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[[Category: Dna-binding protein]]
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[[Category: Moore MH]]
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[[Category: Enzyme]]
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[[Category: Methyltransferase]]
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[[Category: Nucleic acid binding protein]]
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[[Category: Transferase]]
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Current revision

ADA O6-METHYLGUANINE-DNA METHYLTRANSFERASE FROM ESCHERICHIA COLI

PDB ID 1sfe

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