1rz6

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[[Image:1rz6.png|left|200px]]
 
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{{STRUCTURE_1rz6| PDB=1rz6 | SCENE= }}
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==Di-haem Cytochrome c Peroxidase, Form IN==
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<StructureSection load='1rz6' size='340' side='right'caption='[[1rz6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1rz6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Marinobacter_nauticus Marinobacter nauticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RZ6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz6 OCA], [https://pdbe.org/1rz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rz6 RCSB], [https://www.ebi.ac.uk/pdbsum/1rz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rz6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P83787_MARNT P83787_MARNT]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rz/1rz6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rz6 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cytochrome c peroxidase (CCP) catalyses the reduction of H(2)O(2) to H(2)O, an important step in the cellular detoxification process. The crystal structure of the di-heme CCP from Pseudomonas nautica 617 was obtained in two different conformations in a redox state with the electron transfer heme reduced. Form IN, obtained at pH 4.0, does not contain Ca(2+) and was refined at 2.2 A resolution. This inactive form presents a closed conformation where the peroxidatic heme adopts a six-ligand coordination, hindering the peroxidatic reaction from taking place. Form OUT is Ca(2+) dependent and was crystallized at pH 5.3 and refined at 2.4 A resolution. This active form shows an open conformation, with release of the distal histidine (His71) ligand, providing peroxide access to the active site. This is the first time that the active and inactive states are reported for a di-heme peroxidase.
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===Di-haem Cytochrome c Peroxidase, Form IN===
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Structural basis for the mechanism of Ca(2+) activation of the di-heme cytochrome c peroxidase from Pseudomonas nautica 617.,Dias JM, Alves T, Bonifacio C, Pereira AS, Trincao J, Bourgeois D, Moura I, Romao MJ Structure. 2004 Jun;12(6):961-73. PMID:15274917<ref>PMID:15274917</ref>
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{{ABSTRACT_PUBMED_15274917}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1rz6" style="background-color:#fffaf0;"></div>
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[[1rz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Marinobacter_hydrocarbonoclasticus Marinobacter hydrocarbonoclasticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ6 OCA].
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==See Also==
==See Also==
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*[[Cytochrome c peroxidase|Cytochrome c peroxidase]]
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*[[Cytochrome c peroxidase 3D structures|Cytochrome c peroxidase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015274917</ref><references group="xtra"/>
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__TOC__
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[[Category: Cytochrome-c peroxidase]]
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</StructureSection>
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[[Category: Marinobacter hydrocarbonoclasticus]]
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[[Category: Large Structures]]
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[[Category: Alves, T.]]
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[[Category: Marinobacter nauticus]]
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[[Category: Bonifacio, C.]]
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[[Category: Alves T]]
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[[Category: Bourgeois, D.]]
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[[Category: Bonifacio C]]
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[[Category: Dias, J M.]]
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[[Category: Bourgeois D]]
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[[Category: Moura, I.]]
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[[Category: Dias JM]]
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[[Category: Pereira, A.]]
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[[Category: Moura I]]
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[[Category: Romao, M J.]]
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[[Category: Pereira A]]
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[[Category: Electron transport]]
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[[Category: Romao MJ]]
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[[Category: Haem]]
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[[Category: Oxidoreductase]]
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[[Category: Peroxidase]]
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Current revision

Di-haem Cytochrome c Peroxidase, Form IN

PDB ID 1rz6

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