1s6a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (00:28, 21 November 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1s6a.png|left|200px]]
 
-
{{STRUCTURE_1s6a| PDB=1s6a | SCENE= }}
+
==The X-ray structure of the cyanobacteria Synechocystis hemoglobin "cyanoglobin" with azide ligand==
 +
<StructureSection load='1s6a' size='340' side='right'caption='[[1s6a]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1s6a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechocystis_sp._PCC_6803 Synechocystis sp. PCC 6803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S6A FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s6a OCA], [https://pdbe.org/1s6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s6a RCSB], [https://www.ebi.ac.uk/pdbsum/1s6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s6a ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TRHBN_SYNY3 TRHBN_SYNY3] Forms a very stable complex with oxygen. The oxygen dissociation rate is 0.011 s(-1).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s6/1s6a_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s6a ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The crystal structures of cyanide and azide-bound forms of the truncated hemoglobin from Synechocystis are presented at 1.8 angstroms resolution. A comparison with the structure of the endogenously liganded protein reveals a conformational shift unprecedented in hemoglobins, and provides the first picture of a hexacoordinate hemoglobin in both the bis-histidyl and the exogenously coordinated states. The structural changes between the different conformations are confined to two regions of the protein; the B helix, and the E helix, including the EF loop. A molecular "hinge" controlling movement of the E helix is observed in the EF loop, which is composed of three principal structural elements: Arg64, the heme-d-propionate, and a three-residue extension of the F helix. Additional features of the structural transition between the two protein conformations are discussed as they relate to the complex ligand-binding behavior observed in hexacoordinate hemoglobins, and the potential physiological function of this class of proteins.
-
===The X-ray structure of the cyanobacteria Synechocystis hemoglobin "cyanoglobin" with azide ligand===
+
Crystallographic analysis of synechocystis cyanoglobin reveals the structural changes accompanying ligand binding in a hexacoordinate hemoglobin.,Trent JT 3rd, Kundu S, Hoy JA, Hargrove MS J Mol Biol. 2004 Aug 20;341(4):1097-108. PMID:15289104<ref>PMID:15289104</ref>
-
{{ABSTRACT_PUBMED_15289104}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 1s6a" style="background-color:#fffaf0;"></div>
-
[[1s6a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp._pcc_6803 Synechocystis sp. pcc 6803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S6A OCA].
+
==See Also==
==See Also==
-
*[[Hemoglobin|Hemoglobin]]
+
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:015289104</ref><references group="xtra"/>
+
__TOC__
-
[[Category: Synechocystis sp. pcc 6803]]
+
</StructureSection>
-
[[Category: Hargrove, M S.]]
+
[[Category: Large Structures]]
-
[[Category: Hoy, J A.]]
+
[[Category: Synechocystis sp. PCC 6803]]
-
[[Category: III, J T.Trent.]]
+
[[Category: Hargrove MS]]
-
[[Category: Kundu, S.]]
+
[[Category: Hoy JA]]
-
[[Category: 2 on 2 helical fold]]
+
[[Category: Kundu S]]
-
[[Category: Cyanobacteria]]
+
[[Category: Trent III JT]]
-
[[Category: Globin]]
+
-
[[Category: Heme]]
+
-
[[Category: Hemoglobin]]
+
-
[[Category: Hexacoordinate]]
+
-
[[Category: Iron]]
+
-
[[Category: Oxygen binding]]
+
-
[[Category: Oxygen storage-transport complex]]
+
-
[[Category: Truncated]]
+

Current revision

The X-ray structure of the cyanobacteria Synechocystis hemoglobin "cyanoglobin" with azide ligand

PDB ID 1s6a

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1s6a"
Personal tools