2pn8
From Proteopedia
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| - | [[Image:2pn8.png|left|200px]] | ||
| - | + | ==Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase)== | |
| - | + | <StructureSection load='2pn8' size='340' side='right'caption='[[2pn8]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2pn8]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PN8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pn8 OCA], [https://pdbe.org/2pn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pn8 RCSB], [https://www.ebi.ac.uk/pdbsum/2pn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pn8 ProSAT]</span></td></tr> |
| - | [[2pn8]] is a 10 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PRDX4_HUMAN PRDX4_HUMAN] Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.<ref>PMID:9388242</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/2pn8_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pn8 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Peroxiredoxin|Peroxiredoxin]] | + | *[[Peroxiredoxin 3D structures|Peroxiredoxin 3D structures]] |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CA]] |
| - | [[Category: Cooper | + | [[Category: Cooper C]] |
| - | + | [[Category: Edwards A]] | |
| - | [[Category: Edwards | + | [[Category: Kavanagh KL]] |
| - | [[Category: Kavanagh | + | [[Category: Oppermann U]] |
| - | [[Category: Oppermann | + | [[Category: Pilka ES]] |
| - | [[Category: Pilka | + | [[Category: Sundstrom M]] |
| - | + | [[Category: Weigelt J]] | |
| - | [[Category: Sundstrom | + | [[Category: Von Delft F]] |
| - | [[Category: Weigelt | + | |
| - | [[Category: | + | |
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Current revision
Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase)
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