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2eu9
From Proteopedia
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| - | [[Image:2eu9.png|left|200px]] | ||
| - | + | ==Crystal Structure of CLK3== | |
| - | + | <StructureSection load='2eu9' size='340' side='right'caption='[[2eu9]], [[Resolution|resolution]] 1.53Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2eu9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EU9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EU9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eu9 OCA], [https://pdbe.org/2eu9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eu9 RCSB], [https://www.ebi.ac.uk/pdbsum/2eu9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eu9 ProSAT]</span></td></tr> |
| - | [[2eu9]] is a 1 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CLK3_HUMAN CLK3_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:9637771</ref> <ref>PMID:19168442</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eu/2eu9_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eu9 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Dual specificity protein kinase|Dual specificity protein kinase]] | + | *[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Aerrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Bullock | + | [[Category: Aerrowsmith C]] |
| - | [[Category: Bunkoczi | + | [[Category: Bullock A]] |
| - | [[Category: Das | + | [[Category: Bunkoczi G]] |
| - | + | [[Category: Das S]] | |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Fedorov | + | [[Category: Fedorov O]] |
| - | [[Category: Gileadi | + | [[Category: Gileadi C]] |
| - | [[Category: Knapp | + | [[Category: Knapp S]] |
| - | [[Category: Papagrigoriou | + | [[Category: Papagrigoriou E]] |
| - | [[Category: Rellos | + | [[Category: Rellos P]] |
| - | [[Category: Savitsky | + | [[Category: Savitsky P]] |
| - | [[Category: Sobott | + | [[Category: Sobott F]] |
| - | [[Category: Sundstrom | + | [[Category: Sundstrom M]] |
| - | [[Category: Turnbull | + | [[Category: Turnbull A]] |
| - | [[Category: Ugochukwu | + | [[Category: Ugochukwu E]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: | + | [[Category: Von Delft F]] |
| - | + | ||
Current revision
Crystal Structure of CLK3
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Categories: Homo sapiens | Large Structures | Aerrowsmith C | Bullock A | Bunkoczi G | Das S | Edwards A | Fedorov O | Gileadi C | Knapp S | Papagrigoriou E | Rellos P | Savitsky P | Sobott F | Sundstrom M | Turnbull A | Ugochukwu E | Weigelt J | Von Delft F
