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2npt

From Proteopedia

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[[Image:2npt.png|left|200px]]
 
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{{STRUCTURE_2npt| PDB=2npt | SCENE= }}
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==Crystal Structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-phox) with human mitogen activated protein kinase kinase kinase 2 phox domain (MAP3K2-phox)==
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<StructureSection load='2npt' size='340' side='right'caption='[[2npt]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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===Crystal Structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-phox) with human mitogen activated protein kinase kinase kinase 2 phox domain (MAP3K2-phox)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2npt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NPT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2npt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npt OCA], [https://pdbe.org/2npt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2npt RCSB], [https://www.ebi.ac.uk/pdbsum/2npt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2npt ProSAT]</span></td></tr>
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[[2npt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPT OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MP2K5_HUMAN MP2K5_HUMAN] Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.<ref>PMID:7759517</ref> <ref>PMID:9384584</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/2npt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2npt ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Mitogen-activated protein kinase|Mitogen-activated protein kinase]]
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*[[Mitogen-activated protein kinase 3D structures|Mitogen-activated protein kinase 3D structures]]
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*[[Mitogen-activated protein kinase kinase 3D structures|Mitogen-activated protein kinase kinase 3D structures]]
*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Mitogen-activated protein kinase kinase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Debreczeni, J.]]
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[[Category: Debreczeni J]]
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[[Category: Delft, F von.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Filippakopoulos P]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Knapp S]]
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[[Category: Knapp, S.]]
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[[Category: Papagrigoriou V]]
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[[Category: Papagrigoriou, V.]]
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[[Category: Sundstrom M]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Turnbull A]]
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[[Category: Sundstrom, M.]]
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[[Category: Von Delft F]]
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[[Category: Turnbull, A.]]
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[[Category: Map kinase kinase 5]]
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[[Category: Map2k5]]
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[[Category: Map3k2]]
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[[Category: Mapk/erk kinase kinase 2]]
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[[Category: Mapkkk2]]
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[[Category: Mek kinase 2]]
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[[Category: Mek5]]
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[[Category: Mekk2]]
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[[Category: Mekk2b]]
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[[Category: Mitogen activated protein kinase kinase 5]]
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[[Category: Mitogen activated protein kinase kinase kinase 2]]
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[[Category: Mkk5]]
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[[Category: Phox]]
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[[Category: Phox-domain]]
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[[Category: Prkmk5]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-phox) with human mitogen activated protein kinase kinase kinase 2 phox domain (MAP3K2-phox)

PDB ID 2npt

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OCA

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