1q72

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[[Image:1q72.png|left|200px]]
 
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{{STRUCTURE_1q72| PDB=1q72 | SCENE= }}
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==Anti-Cocaine Antibody M82G2 Complexed with Cocaine==
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<StructureSection load='1q72' size='340' side='right'caption='[[1q72]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1q72]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q72 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COC:COCAINE'>COC</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q72 OCA], [https://pdbe.org/1q72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q72 RCSB], [https://www.ebi.ac.uk/pdbsum/1q72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q72 ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q7/1q72_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q72 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Antibodies against cocaine and other drugs of abuse are the basis for diagnostic tests for the presence of those drugs in human serum. The 1.7A resolution crystal structure of the anti-cocaine monoclonal antibody M82G2 in complex with cocaine is presented. This structure determination was undertaken to establish the stereochemical features in the antibody binding site that confer specificity for cocaine, and as part of an ongoing project to understand the rules that govern molecular recognition. The cocaine-binding site can be characterized topologically as a narrow groove on the protein surface. The antibody utilizes water-mediated hydrogen bonding, and cation-pi and stacking (pi-pi) interactions to provide specificity. Comparison with the previously published structure of the anti-cocaine antibody GNC92H2 shows that binding of a small ligand can be achieved in diverse ways, both in terms of a binding site structure/topology and protein-ligand interactions.
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===Anti-Cocaine Antibody M82G2 Complexed with Cocaine===
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Diversity in hapten recognition: structural study of an anti-cocaine antibody M82G2.,Pozharski E, Moulin A, Hewagama A, Shanafelt AB, Petsko GA, Ringe D J Mol Biol. 2005 Jun 10;349(3):570-82. Epub 2005 Apr 21. PMID:15885702<ref>PMID:15885702</ref>
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{{ABSTRACT_PUBMED_15885702}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1q72" style="background-color:#fffaf0;"></div>
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[[1q72]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q72 OCA].
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==See Also==
==See Also==
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*[[Antibody|Antibody]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:015885702</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Hewagama, A.]]
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[[Category: Hewagama A]]
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[[Category: Moulin, A.]]
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[[Category: Moulin A]]
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[[Category: Petsko, G A.]]
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[[Category: Petsko GA]]
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[[Category: Pozharski, E.]]
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[[Category: Pozharski E]]
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[[Category: Ringe, D.]]
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[[Category: Ringe D]]
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[[Category: Shanafelt, A B.]]
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[[Category: Shanafelt AB]]
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[[Category: Anti-cocaine antibody]]
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[[Category: Fab]]
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[[Category: Immune system]]
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Current revision

Anti-Cocaine Antibody M82G2 Complexed with Cocaine

PDB ID 1q72

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