1nkt

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[[Image:1nkt.png|left|200px]]
 
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{{STRUCTURE_1nkt| PDB=1nkt | SCENE= }}
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==CRYSTAL STRUCTURE OF THE SECA PROTEIN TRANSLOCATION ATPASE FROM MYCOBACTERIUM TUBERCULOSIS COMPLEX WITH ADPBS==
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<StructureSection load='1nkt' size='340' side='right'caption='[[1nkt]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF THE SECA PROTEIN TRANSLOCATION ATPASE FROM MYCOBACTERIUM TUBERCULOSIS COMPLEX WITH ADPBS===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nkt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NKT FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12606717}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.601&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nkt OCA], [https://pdbe.org/1nkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nkt RCSB], [https://www.ebi.ac.uk/pdbsum/1nkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nkt ProSAT]</span></td></tr>
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[[1nkt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NKT OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SECA1_MYCTU SECA1_MYCTU] Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of precursor proteins, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nk/1nkt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nkt ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Preprotein translocase 3D structures|Preprotein translocase 3D structures]]
*[[SecA|SecA]]
*[[SecA|SecA]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:012606717</ref><ref group="xtra">PMID:016754988</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Arockiasamy, A.]]
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[[Category: Arockiasamy A]]
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[[Category: Braunstein, M.]]
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[[Category: Braunstein M]]
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[[Category: Holzenburg, A.]]
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[[Category: Holzenburg A]]
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[[Category: Jacobs, W R.]]
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[[Category: Jacobs Jr WR]]
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[[Category: Ronning, D R.]]
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[[Category: Ronning DR]]
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[[Category: Sacchettini, J C.]]
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[[Category: Sacchettini JC]]
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[[Category: Savva, C G.]]
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[[Category: Savva CG]]
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[[Category: Sharma, V.]]
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[[Category: Sharma V]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Atpase]]
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[[Category: Helicase-like motor domain]]
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[[Category: Preprotein translocation]]
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[[Category: Protein structure initiative]]
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[[Category: Protein transport]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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[[Category: Transmembrane transport]]
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Current revision

CRYSTAL STRUCTURE OF THE SECA PROTEIN TRANSLOCATION ATPASE FROM MYCOBACTERIUM TUBERCULOSIS COMPLEX WITH ADPBS

PDB ID 1nkt

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