3ef9
From Proteopedia
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| - | [[Image:3ef9.png|left|200px]] | ||
| - | + | ==Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability== | |
| - | + | <StructureSection load='3ef9' size='340' side='right'caption='[[3ef9]], [[Resolution|resolution]] 3.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3ef9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EF9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ef9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ef9 OCA], [https://pdbe.org/3ef9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ef9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ef9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ef9 ProSAT]</span></td></tr> |
| - | [[3ef9]] is a 1 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/3ef9_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ef9 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Thymidylate synthase|Thymidylate synthase]] | + | *[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Bell | + | [[Category: Bell BJ]] |
| - | [[Category: Berger | + | [[Category: Berger FG]] |
| - | [[Category: Berger | + | [[Category: Berger SH]] |
| - | [[Category: Gibson | + | [[Category: Gibson LM]] |
| - | [[Category: Huang | + | [[Category: Huang X]] |
| - | [[Category: Lovelace | + | [[Category: Lovelace LL]] |
| - | [[Category: Pena | + | [[Category: Pena MM]] |
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Current revision
Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability
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Categories: Homo sapiens | Large Structures | Bell BJ | Berger FG | Berger SH | Gibson LM | Huang X | Lovelace LL | Pena MM
