2w0d

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[[Image:2w0d.png|left|200px]]
 
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{{STRUCTURE_2w0d| PDB=2w0d | SCENE= }}
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==Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach Provide Reliable Structural Information of Ligand-Protein Complexes? A Case Study of Metalloproteinases.==
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<StructureSection load='2w0d' size='340' side='right'caption='[[2w0d]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach Provide Reliable Structural Information of Ligand-Protein Complexes? A Case Study of Metalloproteinases.===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2w0d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W0D FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19239231}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CGS:N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE+HYDROCHLORIDE'>CGS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0d OCA], [https://pdbe.org/2w0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w0d RCSB], [https://www.ebi.ac.uk/pdbsum/2w0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w0d ProSAT]</span></td></tr>
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[[2w0d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0D OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w0/2w0d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w0d ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Elastase|Elastase]]
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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*[[Matrix metalloproteinase|Matrix metalloproteinase]]
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019239231</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Macrophage elastase]]
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[[Category: Large Structures]]
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[[Category: Agback, T.]]
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[[Category: Agback T]]
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[[Category: Bertini, I.]]
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[[Category: Bertini I]]
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[[Category: Derbyshire, D J.]]
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[[Category: Derbyshire DJ]]
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[[Category: Felli, I C.]]
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[[Category: Felli IC]]
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[[Category: Isaksson, J.]]
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[[Category: Isaksson J]]
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[[Category: Kovacs, H.]]
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[[Category: Kovacs H]]
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[[Category: Nystrom, S.]]
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[[Category: Nystrom S]]
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[[Category: Wallberg, H.]]
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[[Category: Wallberg H]]
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[[Category: Copd]]
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[[Category: Extracellular matrix]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Hydroxamate]]
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[[Category: Metal-binding]]
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[[Category: Metalloprotease]]
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[[Category: Mmp-12]]
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[[Category: Secreted]]
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[[Category: Zymogen]]
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Current revision

Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach Provide Reliable Structural Information of Ligand-Protein Complexes? A Case Study of Metalloproteinases.

PDB ID 2w0d

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