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1ero

From Proteopedia

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[[Image:1ero.png|left|200px]]
 
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{{STRUCTURE_1ero| PDB=1ero | SCENE= }}
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==X-RAY CRYSTAL STRUCTURE OF TEM-1 BETA LACTAMASE IN COMPLEX WITH A DESIGNED BORONIC ACID INHIBITOR (1R)-2-PHENYLACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID==
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<StructureSection load='1ero' size='340' side='right'caption='[[1ero]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===X-RAY CRYSTAL STRUCTURE OF TEM-1 BETA LACTAMASE IN COMPLEX WITH A DESIGNED BORONIC ACID INHIBITOR (1R)-2-PHENYLACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ero]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ERO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ERO FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10820001}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BJP:(1R)-2-PHENYLACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL+BORONIC+ACID'>BJP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ero FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ero OCA], [https://pdbe.org/1ero PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ero RCSB], [https://www.ebi.ac.uk/pdbsum/1ero PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ero ProSAT]</span></td></tr>
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[[1ero]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ERO OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/1ero_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ero ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Beta-lactamase|Beta-lactamase]]
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:010820001</ref><references group="xtra"/>
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[[Category: Beta-lactamase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Gold, M.]]
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[[Category: Large Structures]]
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[[Category: Jones, J B.]]
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[[Category: Gold M]]
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[[Category: Kindler, A M.]]
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[[Category: Jones JB]]
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[[Category: Martin, R.]]
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[[Category: Kindler AM]]
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[[Category: Ness, S.]]
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[[Category: Martin R]]
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[[Category: Paetzel, M.]]
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[[Category: Ness S]]
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[[Category: Strynadka, N C.J.]]
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[[Category: Paetzel M]]
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[[Category: Beta-lactamase]]
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[[Category: Strynadka NCJ]]
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[[Category: Boronate inhibitor]]
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[[Category: Hydrolase]]
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[[Category: Structure-based design]]
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Current revision

X-RAY CRYSTAL STRUCTURE OF TEM-1 BETA LACTAMASE IN COMPLEX WITH A DESIGNED BORONIC ACID INHIBITOR (1R)-2-PHENYLACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID

PDB ID 1ero

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