3k92

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[[Image:3k92.png|left|200px]]
 
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{{STRUCTURE_3k92| PDB=3k92 | SCENE= }}
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==Crystal structure of a E93K mutant of the majour Bacillus subtilis glutamate dehydrogenase RocG==
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<StructureSection load='3k92' size='340' side='right'caption='[[3k92]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===Crystal structure of a E93K mutant of the majour Bacillus subtilis glutamate dehydrogenase RocG===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3k92]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K92 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_020630473}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k92 OCA], [https://pdbe.org/3k92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k92 RCSB], [https://www.ebi.ac.uk/pdbsum/3k92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k92 ProSAT]</span></td></tr>
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[[3k92]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K92 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DHE2_BACSU DHE2_BACSU] Devoted to catabolic function of glutamate (and other amino acids of the glutamate family) utilization as sole nitrogen source. It is not involved in anabolic function of glutamate biosynthesis since B.subtilis possesses only one route of glutamate biosynthesis from ammonia, catalyzed by glutamate synthase. RocG is unable to utilize glutamate or glutamine as sole carbon source and to synthesize glutamate, but it is involved in the utilization of arginine, and proline as carbon or nitrogen source. The catabolic RocG is essential for controlling gltAB expression via an inhibitory interactions with the transcriptional regulator GltC in response to the availability of sugars.<ref>PMID:9829940</ref> <ref>PMID:17183217</ref> <ref>PMID:18326565</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k9/3k92_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k92 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Glutamate dehydrogenase|Glutamate dehydrogenase]]
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*[[Glutamate dehydrogenase 3D structures|Glutamate dehydrogenase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020630473</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Glutamate dehydrogenase]]
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[[Category: Large Structures]]
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[[Category: Commichau, F M.]]
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[[Category: Commichau FM]]
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[[Category: Gunka, K.]]
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[[Category: Gunka K]]
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[[Category: Herzberg, C.]]
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[[Category: Herzberg C]]
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[[Category: Hewitt, L.]]
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[[Category: Hewitt L]]
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[[Category: Lewis, R J.]]
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[[Category: Lewis RJ]]
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[[Category: Newman, J A.]]
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[[Category: Newman JA]]
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[[Category: Rodrigues, C.]]
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[[Category: Rodrigues C]]
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[[Category: Stulke, J.]]
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[[Category: Stulke J]]
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[[Category: Glutamate dehydrogenase]]
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[[Category: Nad]]
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[[Category: Oxidoreductase]]
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[[Category: Rocg]]
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Current revision

Crystal structure of a E93K mutant of the majour Bacillus subtilis glutamate dehydrogenase RocG

PDB ID 3k92

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