1k86

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:44, 7 February 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1k86.png|left|200px]]
 
-
{{STRUCTURE_1k86| PDB=1k86 | SCENE= }}
+
==Crystal structure of caspase-7==
-
 
+
<StructureSection load='1k86' size='340' side='right'caption='[[1k86]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-
===Crystal structure of caspase-7===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1k86]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K86 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_11701129}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k86 OCA], [https://pdbe.org/1k86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k86 RCSB], [https://www.ebi.ac.uk/pdbsum/1k86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k86 ProSAT]</span></td></tr>
-
==About this Structure==
+
</table>
-
[[1k86]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K86 OCA].
+
== Function ==
 +
[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k8/1k86_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k86 ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Caspase|Caspase]]
+
*[[Caspase 3D structures|Caspase 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:011701129</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Alnemri, E S.]]
+
[[Category: Large Structures]]
-
[[Category: Chai, J.]]
+
[[Category: Alnemri ES]]
-
[[Category: Shi, Y.]]
+
[[Category: Chai J]]
-
[[Category: Shiozaki, E.]]
+
[[Category: Shi Y]]
-
[[Category: Srinivasa, S M.]]
+
[[Category: Shiozaki E]]
-
[[Category: Wu, Q.]]
+
[[Category: Srinivasa SM]]
-
[[Category: Activation]]
+
[[Category: Wu Q]]
-
[[Category: Apoptosis]]
+
-
[[Category: Caspase]]
+
-
[[Category: Zymogen]]
+

Current revision

Crystal structure of caspase-7

PDB ID 1k86

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k86"
Personal tools