3ui7

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[[Image:3ui7.png|left|200px]]
 
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{{STRUCTURE_3ui7| PDB=3ui7 | SCENE= }}
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==Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia==
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<StructureSection load='3ui7' size='340' side='right'caption='[[3ui7]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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===Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ui7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UI7 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22142545}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C1L:6-METHOXY-3,8-DIMETHYL-4-(MORPHOLIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-B]QUINOLINE'>C1L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ui7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ui7 OCA], [https://pdbe.org/3ui7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ui7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ui7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ui7 ProSAT]</span></td></tr>
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[[3ui7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UI7 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
==See Also==
==See Also==
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*[[Phosphodiesterase|Phosphodiesterase]]
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022142545</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Greenlee, W J.]]
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[[Category: Large Structures]]
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[[Category: Ho, G.]]
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[[Category: Greenlee WJ]]
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[[Category: Hodgson, R.]]
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[[Category: Ho G]]
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[[Category: Hruza, A.]]
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[[Category: Hodgson R]]
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[[Category: Mcelroy, W.]]
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[[Category: Hruza A]]
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[[Category: Smotryski, J.]]
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[[Category: Mcelroy W]]
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[[Category: Tulshian, D.]]
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[[Category: Smotryski J]]
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[[Category: Xiao, L.]]
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[[Category: Tulshian D]]
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[[Category: Yang, S.]]
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[[Category: Xiao L]]
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[[Category: Hydrolase]]
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[[Category: Yang S]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Inhibitor complex]]
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[[Category: Mg binding]]
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[[Category: Zn binding]]
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Current revision

Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia

PDB ID 3ui7

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