2lbv

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[[Image:2lbv.png|left|200px]]
 
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{{STRUCTURE_2lbv| PDB=2lbv | SCENE= }}
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==Siderocalin Q83 reveals a dual ligand binding mode==
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<StructureSection load='2lbv' size='340' side='right'caption='[[2lbv]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lbv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Coturnix_japonica Coturnix japonica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LBV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene>, <scene name='pdbligand=EB4:N,N,N-[(3S,7S,11S)-2,6,10-TRIOXO-1,5,9-TRIOXACYCLODODECANE-3,7,11-TRIYL]TRIS(2,3-DIHYDROXYBENZAMIDE)'>EB4</scene>, <scene name='pdbligand=GA:GALLIUM+(III)+ION'>GA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lbv OCA], [https://pdbe.org/2lbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lbv RCSB], [https://www.ebi.ac.uk/pdbsum/2lbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lbv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EXFAB_COTJA EXFAB_COTJA] Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid. May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor.<ref>PMID:20826777</ref> <ref>PMID:21951132</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Siderocalins are particular lipocalins that participate in the innate immune response by interfering with bacterial siderophore-mediated iron uptake. Additionally, siderocalins are involved in several physiological and pathological processes such as inflammation, iron delivery, tissue differentiation, and cancer progression. Here we show that siderocalin Q83 displays an unexpected dual ligand binding mode as it can bind enterobactin and unsaturated fatty acids simultaneously. The solution structure of the siderocalin Q83 in complex with arachidonic acid and enterobactin reveals molecular details of this novel dual binding mode and the determinants of fatty acid binding specificity. Our results suggest that Q83 is a metabolic hub linking iron and fatty acid pathways. This unexpected coupling might contribute to the pleiotropic functions of siderocalins.
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===Siderocalin Q83 reveals a dual ligand binding mode===
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Lipocalin Q83 reveals a dual ligand binding mode with potential implications for the functions of siderocalins.,Coudevylle N, Hoetzinger M, Geist L, Kontaxis G, Hartl M, Bister K, Konrat R Biochemistry. 2011 Nov 1;50(43):9192-9. Epub 2011 Oct 7. PMID:21951132<ref>PMID:21951132</ref>
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{{ABSTRACT_PUBMED_21951132}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2lbv" style="background-color:#fffaf0;"></div>
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[[2lbv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Coturnix_japonica Coturnix japonica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBV OCA].
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==See Also==
==See Also==
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*[[Fatty acid-binding protein|Fatty acid-binding protein]]
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*[[Siderocalin 3D structures|Siderocalin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021951132</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Coturnix japonica]]
[[Category: Coturnix japonica]]
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[[Category: Bister, K.]]
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[[Category: Large Structures]]
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[[Category: Coudevylle, N.]]
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[[Category: Bister K]]
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[[Category: Geist, L.]]
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[[Category: Coudevylle N]]
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[[Category: Hoetzinger, M.]]
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[[Category: Geist L]]
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[[Category: Konrat, R.]]
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[[Category: Hoetzinger M]]
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[[Category: Kontaxis, G.]]
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[[Category: Konrat R]]
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[[Category: Arachidonic acid]]
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[[Category: Kontaxis G]]
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[[Category: Enterobactin]]
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[[Category: Lipid transport]]
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[[Category: Lipocalin]]
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[[Category: Siderocalin]]
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Current revision

Siderocalin Q83 reveals a dual ligand binding mode

PDB ID 2lbv

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