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3c5w

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[[Image:3c5w.png|left|200px]]
 
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{{STRUCTURE_3c5w| PDB=3c5w | SCENE= }}
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==Complex between PP2A-specific methylesterase PME-1 and PP2A core enzyme==
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<StructureSection load='3c5w' size='340' side='right'caption='[[3c5w]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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===Complex between PP2A-specific methylesterase PME-1 and PP2A core enzyme===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3c5w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C5W FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18394995}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5w OCA], [https://pdbe.org/3c5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c5w RCSB], [https://www.ebi.ac.uk/pdbsum/3c5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5w ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3c5w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5W OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/2AAA_HUMAN 2AAA_HUMAN] The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.<ref>PMID:16580887</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/3c5w_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c5w ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Methylesterase|Methylesterase]]
*[[Methylesterase|Methylesterase]]
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*[[Methylesterase 3D structures|Methylesterase 3D structures]]
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==Reference==
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*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
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<ref group="xtra">PMID:018394995</ref><references group="xtra"/>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, Y.]]
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[[Category: Large Structures]]
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[[Category: Jeffrey, P D.]]
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[[Category: Chen Y]]
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[[Category: Li, Z.]]
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[[Category: Jeffrey PD]]
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[[Category: Shi, Y.]]
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[[Category: Li Z]]
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[[Category: Stock, J.]]
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[[Category: Shi Y]]
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[[Category: Xing, Y.]]
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[[Category: Stock J]]
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[[Category: Hydrolase]]
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[[Category: Xing Y]]
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[[Category: Methylesterase]]
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[[Category: Phosphatase]]
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[[Category: Pp2a]]
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Current revision

Complex between PP2A-specific methylesterase PME-1 and PP2A core enzyme

PDB ID 3c5w

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