1whv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:40, 9 May 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1whv.png|left|200px]]
 
-
{{STRUCTURE_1whv| PDB=1whv | SCENE= }}
+
==Solution structure of the RNA binding domain from hypothetical protein BAB23382==
-
 
+
<StructureSection load='1whv' size='340' side='right'caption='[[1whv]]' scene=''>
-
===Solution structure of the RNA binding domain from hypothetical protein BAB23382===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1whv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WHV FirstGlance]. <br>
-
 
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1whv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1whv OCA], [https://pdbe.org/1whv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1whv RCSB], [https://www.ebi.ac.uk/pdbsum/1whv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1whv ProSAT], [https://www.topsan.org/Proteins/RSGI/1whv TOPSAN]</span></td></tr>
-
[[1whv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHV OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PARN_MOUSE PARN_MOUSE] 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wh/1whv_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1whv ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Ribonuclease|Ribonuclease]]
+
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Inoue, M.]]
+
[[Category: Inoue M]]
-
[[Category: Kigawa, T.]]
+
[[Category: Kigawa T]]
-
[[Category: Muto, Y.]]
+
[[Category: Muto Y]]
-
[[Category: Nagata, T.]]
+
[[Category: Nagata T]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Shirouzu M]]
-
[[Category: Shirouzu, M.]]
+
[[Category: Terada T]]
-
[[Category: Terada, T.]]
+
[[Category: Yokoyama S]]
-
[[Category: Yokoyama, S.]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Parn]]
+
-
[[Category: Rbd]]
+
-
[[Category: Riken structural genomics/proteomics initiative]]
+
-
[[Category: Rna binding domain]]
+
-
[[Category: Rna recognition motif]]
+
-
[[Category: Rnp]]
+
-
[[Category: Rrm]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Structural genomic]]
+

Current revision

Solution structure of the RNA binding domain from hypothetical protein BAB23382

PDB ID 1whv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1whv"
Personal tools