3mya

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[[Image:3mya.png|left|200px]]
 
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{{STRUCTURE_3mya| PDB=3mya | SCENE= }}
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==Crystal Structure of HP67 H41F - P61==
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<StructureSection load='3mya' size='340' side='right'caption='[[3mya]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3mya]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MYA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mya OCA], [https://pdbe.org/3mya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mya RCSB], [https://www.ebi.ac.uk/pdbsum/3mya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mya ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VILI_CHICK VILI_CHICK] Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair (By similarity). Its actin-bundling activity is inhibited by tropomyosin.<ref>PMID:3793760</ref> <ref>PMID:1618806</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Villin headpiece is a small autonomously folding protein that has emerged as a model system for understanding the fundamental tenets governing protein folding. In this communication, we employ NMR and X-ray crystallography to characterize a point mutant, H41F, which retains actin-binding activity, is more thermostable but, interestingly, does not exhibit the partially folded intermediate observed of either wild-type or other similar point mutants.
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===Crystal Structure of HP67 H41F - P61===
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On Unsatisfied Hydrogen Bonds in the N-Terminal Subdomain of Villin Headpiece.,Brown JW, Farelli JD, McKnight CJ J Mol Biol. 2011 Aug 31. PMID:21903098<ref>PMID:21903098</ref>
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{{ABSTRACT_PUBMED_21903098}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3mya" style="background-color:#fffaf0;"></div>
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[[3mya]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MYA OCA].
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==See Also==
==See Also==
*[[Villin|Villin]]
*[[Villin|Villin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021903098</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Brown, J W.]]
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[[Category: Large Structures]]
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[[Category: Farelli, J D.]]
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[[Category: Brown JW]]
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[[Category: McKnight, C J.]]
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[[Category: Farelli JD]]
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[[Category: Alpha helix]]
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[[Category: McKnight CJ]]
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[[Category: Protein]]
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[[Category: Structural protein]]
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[[Category: Villin headpiece]]
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Current revision

Crystal Structure of HP67 H41F - P61

PDB ID 3mya

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