2r59

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[[Image:2r59.png|left|200px]]
 
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{{STRUCTURE_2r59| PDB=2r59 | SCENE= }}
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==Leukotriene A4 hydrolase complexed with inhibitor RB3041==
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<StructureSection load='2r59' size='340' side='right'caption='[[2r59]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
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===Leukotriene A4 hydrolase complexed with inhibitor RB3041===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2r59]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R59 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18804029}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PH0:N-{(2S)-3-[(R)-[(1R)-1-AMINO-2-PHENYLETHYL](HYDROXY)PHOSPHORYL]-2-BENZYLPROPANOYL}-L-PHENYLALANINE'>PH0</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r59 OCA], [https://pdbe.org/2r59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r59 RCSB], [https://www.ebi.ac.uk/pdbsum/2r59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r59 ProSAT]</span></td></tr>
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[[2r59]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R59 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r59_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r59 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Leukotriene A4 Hydrolase|Leukotriene A4 Hydrolase]]
*[[Leukotriene A4 Hydrolase|Leukotriene A4 Hydrolase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018804029</ref><ref group="xtra">PMID:017357161</ref><ref group="xtra">PMID:015078870</ref><ref group="xtra">PMID:011675384</ref><ref group="xtra">PMID:011917124</ref><ref group="xtra">PMID:011175901</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fournie-Zaluski, M C.]]
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[[Category: Large Structures]]
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[[Category: Haeggstrom, J Z.]]
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[[Category: Fournie-Zaluski MC]]
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[[Category: Muroya, A.]]
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[[Category: Haeggstrom JZ]]
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[[Category: Roques, B P.]]
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[[Category: Muroya A]]
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[[Category: Tholander, F.]]
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[[Category: Roques BP]]
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[[Category: Thunnissen, M.]]
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[[Category: Tholander F]]
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[[Category: Analogue peptide]]
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[[Category: Thunnissen M]]
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[[Category: Hydrolase]]
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[[Category: Hydrolysis]]
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[[Category: Leukotriene biosynthesis]]
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[[Category: Metal-binding]]
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[[Category: Metalloprotease]]
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[[Category: Multifunctional enzyme]]
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[[Category: Protease]]
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[[Category: Transition state]]
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Current revision

Leukotriene A4 hydrolase complexed with inhibitor RB3041

PDB ID 2r59

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