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2a5y

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[[Image:2a5y.png|left|200px]]
 
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{{STRUCTURE_2a5y| PDB=2a5y | SCENE= }}
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==Structure of a CED-4/CED-9 complex==
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<StructureSection load='2a5y' size='340' side='right'caption='[[2a5y]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===Structure of a CED-4/CED-9 complex===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2a5y]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. The September 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Apoptosomes'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_9 10.2210/rcsb_pdb/mom_2014_9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A5Y FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16208361}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a5y OCA], [https://pdbe.org/2a5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a5y RCSB], [https://www.ebi.ac.uk/pdbsum/2a5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a5y ProSAT]</span></td></tr>
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[[2a5y]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5Y OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CED9_CAEEL CED9_CAEEL] Plays a major role in programmed cell death (PCD, apoptosis). Egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3.<ref>PMID:7907274</ref> <ref>PMID:9024666</ref> <ref>PMID:9027313</ref> <ref>PMID:9604928</ref> <ref>PMID:10688797</ref> <ref>PMID:15383288</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a5/2a5y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a5y ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cell death protein|Cell death protein]]
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*[[Cell death protein 3D structures|Cell death protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016208361</ref><ref group="xtra">PMID:020844150</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Apoptosomes]]
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Gu, L.]]
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[[Category: Large Structures]]
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[[Category: Hao, Q.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Liu, Q.]]
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[[Category: Gu L]]
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[[Category: Shi, Y.]]
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[[Category: Hao Q]]
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[[Category: Yan, N.]]
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[[Category: Liu Q]]
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[[Category: Apoptosis]]
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[[Category: Shi Y]]
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[[Category: Ced-3 activation]]
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[[Category: Yan N]]
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[[Category: Ced-4]]
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[[Category: Ced-9]]
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Current revision

Structure of a CED-4/CED-9 complex

PDB ID 2a5y

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