1wsz
From Proteopedia
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| - | [[Image:1wsz.png|left|200px]] | ||
| - | + | ==Mutant human ABO(H) blood group transferase A== | |
| - | + | <StructureSection load='1wsz' size='340' side='right'caption='[[1wsz]], [[Resolution|resolution]] 1.59Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1wsz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WSZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wsz OCA], [https://pdbe.org/1wsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wsz RCSB], [https://www.ebi.ac.uk/pdbsum/1wsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wsz ProSAT]</span></td></tr> |
| - | [[1wsz]] is a 1 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ws/1wsz_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wsz ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | + | *[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]] | |
| - | *[[Glycosyltransferase|Glycosyltransferase]] | + | __TOC__ |
| - | + | </StructureSection> | |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Barry | + | [[Category: Large Structures]] |
| - | [[Category: Blancher | + | [[Category: Barry CH]] |
| - | [[Category: Borisova | + | [[Category: Blancher A]] |
| - | [[Category: Evans | + | [[Category: Borisova SN]] |
| - | [[Category: Lee | + | [[Category: Evans SV]] |
| - | [[Category: Palcic | + | [[Category: Lee HJ]] |
| - | [[Category: Seto | + | [[Category: Palcic MM]] |
| - | [[Category: Zheng | + | [[Category: Seto NOL]] |
| - | + | [[Category: Zheng RB]] | |
Current revision
Mutant human ABO(H) blood group transferase A
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Categories: Homo sapiens | Large Structures | Barry CH | Blancher A | Borisova SN | Evans SV | Lee HJ | Palcic MM | Seto NOL | Zheng RB
