3p23

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[[Image:3p23.png|left|200px]]
 
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{{STRUCTURE_3p23| PDB=3p23 | SCENE= }}
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==Crystal structure of the Human kinase and RNase domains in complex with ADP==
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<StructureSection load='3p23' size='340' side='right'caption='[[3p23]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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===Crystal structure of the Human kinase and RNase domains in complex with ADP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3p23]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P23 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21317875}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p23 OCA], [https://pdbe.org/3p23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p23 RCSB], [https://www.ebi.ac.uk/pdbsum/3p23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p23 ProSAT]</span></td></tr>
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[[3p23]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P23 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ERN1_HUMAN ERN1_HUMAN] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:9637683</ref> <ref>PMID:11175748</ref> <ref>PMID:12637535</ref> [UniProtKB:Q9EQY0]
==See Also==
==See Also==
*[[Ire1|Ire1]]
*[[Ire1|Ire1]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021317875</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ali, M M.U.]]
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[[Category: Large Structures]]
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[[Category: Pearl, L H.]]
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[[Category: Ali MMU]]
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[[Category: Atp binding ssrna binding]]
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[[Category: Pearl LH]]
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[[Category: Dephosphorylated]]
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[[Category: Hydrolase]]
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[[Category: Kinase and rnase function]]
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[[Category: Kinase domain]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the Human kinase and RNase domains in complex with ADP

PDB ID 3p23

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