2b2n

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[[Image:2b2n.png|left|200px]]
 
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{{STRUCTURE_2b2n| PDB=2b2n | SCENE= }}
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==Structure of transcription-repair coupling factor==
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<StructureSection load='2b2n' size='340' side='right'caption='[[2b2n]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Structure of transcription-repair coupling factor===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2b2n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B2N FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16309703}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2n OCA], [https://pdbe.org/2b2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b2n RCSB], [https://www.ebi.ac.uk/pdbsum/2b2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b2n ProSAT]</span></td></tr>
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[[2b2n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2N OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MFD_ECOLI MFD_ECOLI] Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site. Can also dissociate RNAP that is blocked by low concentration of nucleoside triphosphates or by physical obstruction, such as bound proteins. In addition, can rescue arrested complexes by promoting forward translocation. Has ATPase activity, which is required for removal of stalled RNAP, but seems to lack helicase activity. May act through a translocase activity that rewinds upstream DNA, leading either to translocation or to release of RNAP when the enzyme active site can not continue elongation.<ref>PMID:8465200</ref> <ref>PMID:7876261</ref> <ref>PMID:7876262</ref> <ref>PMID:12086674</ref> <ref>PMID:19700770</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b2/2b2n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b2n ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Transcription-repair coupling factor|Transcription-repair coupling factor]]
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*[[Transcription-repair coupling factor 3D structures|Transcription-repair coupling factor 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016309703</ref><references group="xtra"/>
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__TOC__
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[[Category: Escherichia coli]]
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</StructureSection>
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[[Category: Assenmacher, N.]]
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[[Category: Escherichia coli K-12]]
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[[Category: Hopfner, K P.]]
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[[Category: Large Structures]]
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[[Category: Lammens, A.]]
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[[Category: Assenmacher N]]
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[[Category: Wenig, K.]]
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[[Category: Hopfner K-P]]
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[[Category: Dna repair]]
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[[Category: Lammens A]]
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[[Category: Rna polymerase]]
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[[Category: Wenig K]]
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[[Category: Rnap]]
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[[Category: Strand-specific repair]]
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[[Category: Template strand]]
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[[Category: Transcription]]
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[[Category: Uvra/b/c repair system]]
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[[Category: X-ray crystallography]]
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Current revision

Structure of transcription-repair coupling factor

PDB ID 2b2n

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