1efy

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[[Image:1efy.png|left|200px]]
 
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{{STRUCTURE_1efy| PDB=1efy | SCENE= }}
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==CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF POLY (ADP-RIBOSE) POLYMERASE COMPLEXED WITH A BENZIMIDAZOLE INHIBITOR==
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<StructureSection load='1efy' size='340' side='right'caption='[[1efy]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF POLY (ADP-RIBOSE) POLYMERASE COMPLEXED WITH A BENZIMIDAZOLE INHIBITOR===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1efy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EFY FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11063605}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BZC:2-(3-METHOXYPHENYL)+BENZIMIDAZOLE-4-CARBOXAMIDE'>BZC</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1efy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1efy OCA], [https://pdbe.org/1efy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1efy RCSB], [https://www.ebi.ac.uk/pdbsum/1efy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1efy ProSAT]</span></td></tr>
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[[1efy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EFY OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PARP1_CHICK PARP1_CHICK] Poly[ADP-ribose] polymerase modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/1efy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1efy ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Poly (ADP-ribose) polymerase|Poly (ADP-ribose) polymerase]]
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*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:011063605</ref><references group="xtra"/>
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Almassy, R.]]
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[[Category: Large Structures]]
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[[Category: Calvert, A H.]]
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[[Category: Almassy R]]
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[[Category: Curtin, N J.]]
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[[Category: Calvert AH]]
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[[Category: Golding, B T.]]
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[[Category: Curtin NJ]]
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[[Category: Griffin, R J.]]
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[[Category: Golding BT]]
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[[Category: Hostomsky, Z.]]
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[[Category: Griffin RJ]]
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[[Category: Maegley, K.]]
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[[Category: Hostomsky Z]]
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[[Category: Newell, D R.]]
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[[Category: Maegley K]]
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[[Category: Srinivasan, S.]]
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[[Category: Newell DR]]
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[[Category: White, A W.]]
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[[Category: Srinivasan S]]
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[[Category: Benzimidazole]]
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[[Category: White AW]]
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[[Category: Catalytic fragment]]
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[[Category: Inhibitor]]
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[[Category: Polymerase]]
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[[Category: Transferase]]
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Current revision

CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF POLY (ADP-RIBOSE) POLYMERASE COMPLEXED WITH A BENZIMIDAZOLE INHIBITOR

PDB ID 1efy

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