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4abj

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[[Image:4abj.png|left|200px]]
 
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{{STRUCTURE_4abj| PDB=4abj | SCENE= }}
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==Co-complex structure of bovine trypsin with a modified Bowman-Birk inhibitor (IcA)SFTI-1(1,14), that was 1,5-disubstituted with 1,2,3- trizol to mimic a cis amide bond==
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<StructureSection load='4abj' size='340' side='right'caption='[[4abj]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4abj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Helianthus_annuus Helianthus annuus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ABJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ABJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMF:DIMETHYLFORMAMIDE'>DMF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLW:(2S)-2-[5-(1S,2S)-(1-AMINO-2-METHYL-BUTYL)-[1,2,3]TRIAZOL-1-YL]-PROPIONIC+ACID'>PLW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4abj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4abj OCA], [https://pdbe.org/4abj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4abj RCSB], [https://www.ebi.ac.uk/pdbsum/4abj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4abj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRY1_BOVIN TRY1_BOVIN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Flower power: Potent protease inhibitors containing triazolyl mimics of cis and trans backbone amides were engineered based on the structure of the sunflower trypsin inhibitor 1. The biologically relevant cis-Pro motif was successfully replaced with a non-prolyl unit. High-resolution crystal structures of 1,4- and 1,5-disubstituted 1,2,3-triazolyl peptidomimetics can serve in the design of tailor-made Bowman-Birk inhibitors.
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===Co-complex structure of bovine trypsin with a modified Bowman-Birk inhibitor (IcA)SFTI-1(1,14), that was 1,5-disubstituted with 1,2,3- trizol to mimic a cis amid bond===
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Braces for the Peptide backbone: insights into structure-activity relationships of protease inhibitor mimics with locked amide conformations.,Tischler M, Nasu D, Empting M, Schmelz S, Heinz DW, Rottmann P, Kolmar H, Buntkowsky G, Tietze D, Avrutina O Angew Chem Int Ed Engl. 2012 Apr 10;51(15):3708-12. doi: 10.1002/anie.201108983. , Epub 2012 Feb 28. PMID:22374650<ref>PMID:22374650</ref>
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{{ABSTRACT_PUBMED_22374650}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 4abj" style="background-color:#fffaf0;"></div>
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[[4abj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ABJ OCA].
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==See Also==
==See Also==
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*[[Trypsin|Trypsin]]
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*[[Trypsin 3D structures|Trypsin 3D structures]]
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*[[Trypsin inhibitor 3D structures|Trypsin inhibitor 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:022374650</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Trypsin]]
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[[Category: Helianthus annuus]]
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[[Category: Empting, M.]]
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[[Category: Large Structures]]
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[[Category: Heinz, D.]]
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[[Category: Empting M]]
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[[Category: Kolmar, H.]]
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[[Category: Heinz D]]
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[[Category: Nasu, D.]]
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[[Category: Kolmar H]]
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[[Category: Schmelz, S.]]
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[[Category: Nasu D]]
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[[Category: Tischler, M.]]
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[[Category: Schmelz S]]
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[[Category: Amide mimic]]
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[[Category: Tischler M]]
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[[Category: Hydrolase-inhibitor complex]]
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Current revision

Co-complex structure of bovine trypsin with a modified Bowman-Birk inhibitor (IcA)SFTI-1(1,14), that was 1,5-disubstituted with 1,2,3- trizol to mimic a cis amide bond

PDB ID 4abj

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