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2g76
From Proteopedia
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| - | [[Image:2g76.png|left|200px]] | ||
| - | + | ==Crystal structure of human 3-phosphoglycerate dehydrogenase== | |
| - | + | <StructureSection load='2g76' size='340' side='right'caption='[[2g76]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2g76]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G76 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |
| - | == | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLT:D-MALATE'>MLT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr> |
| - | [[2g76]] is a 2 chain structure with sequence from [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g76 OCA], [https://pdbe.org/2g76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g76 RCSB], [https://www.ebi.ac.uk/pdbsum/2g76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g76 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[https://omim.org/entry/601815 601815]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g7/2g76_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g76 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Phosphoglycerate dehydrogenase|Phosphoglycerate dehydrogenase]] | *[[Phosphoglycerate dehydrogenase|Phosphoglycerate dehydrogenase]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith C]] |
| - | + | [[Category: Edwards A]] | |
| - | [[Category: Edwards | + | [[Category: Gileadi O]] |
| - | [[Category: Gileadi | + | [[Category: Oppermann U]] |
| - | [[Category: Oppermann | + | [[Category: Salah E]] |
| - | + | [[Category: Savitsky P]] | |
| - | [[Category: Salah | + | [[Category: Sundstrom M]] |
| - | [[Category: Savitsky | + | [[Category: Turnbull AP]] |
| - | [[Category: Sundstrom | + | [[Category: Weigelt J]] |
| - | [[Category: Turnbull | + | [[Category: Von Delft F]] |
| - | [[Category: Weigelt | + | |
| - | [[Category: | + | |
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Current revision
Crystal structure of human 3-phosphoglycerate dehydrogenase
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Edwards A | Gileadi O | Oppermann U | Salah E | Savitsky P | Sundstrom M | Turnbull AP | Weigelt J | Von Delft F
