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3e1s

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[[Image:3e1s.png|left|200px]]
 
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{{STRUCTURE_3e1s| PDB=3e1s | SCENE= }}
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==Structure of an N-terminal truncation of Deinococcus radiodurans RecD2==
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<StructureSection load='3e1s' size='340' side='right'caption='[[3e1s]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Structure of an N-terminal truncation of Deinococcus radiodurans RecD2===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3e1s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E1S FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18668125}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e1s OCA], [https://pdbe.org/3e1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e1s RCSB], [https://www.ebi.ac.uk/pdbsum/3e1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e1s ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3e1s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E1S OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/RECDL_DEIRA RECDL_DEIRA] DNA-dependent ATPase (ssDNA better than dsDNA) and ATP-dependent 5'-3' DNA helicase. Appears to move along DNA in single base steps, powered by hydrolysis of 1 molecule of ATP. Has low processivity; short (20 bp) substrates with 5'-overhangs or forked ends are the best substrates, is much less efficient on 52 or 76 bp substrates with 5'- overhangs. The presence of single-stranded DNA-binding protein (SSB) increases unwinding 4-5 fold. Has no activity on blunt DNA or DNA with 3'-overhangs. Requires at least 10 bases of 5'-ssDNA for helicase activity.<ref>PMID:15466873</ref> <ref>PMID:19490894</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/3e1s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e1s ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Exonuclease|Exonuclease]]
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*[[Exonuclease 3D structures|Exonuclease 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018668125</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
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[[Category: Cook, N.]]
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[[Category: Large Structures]]
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[[Category: Court, R.]]
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[[Category: Cook N]]
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[[Category: Griffiths, S P.]]
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[[Category: Court R]]
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[[Category: Saikrishnan, K.]]
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[[Category: Griffiths SP]]
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[[Category: Wigley, D B.]]
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[[Category: Saikrishnan K]]
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[[Category: Alpha and beta protein]]
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[[Category: Wigley DB]]
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[[Category: Atp-binding]]
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[[Category: Hydrolase]]
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[[Category: Nucleotide-binding]]
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Current revision

Structure of an N-terminal truncation of Deinococcus radiodurans RecD2

PDB ID 3e1s

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