1tue
From Proteopedia
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| - | [[Image:1tue.png|left|200px]] | ||
| - | + | ==The X-ray Structure of the Papillomavirus Helicase in Complex with its Molecular Matchmaker E2== | |
| - | + | <StructureSection load='1tue' size='340' side='right'caption='[[1tue]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1tue]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TUE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tue OCA], [https://pdbe.org/1tue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tue RCSB], [https://www.ebi.ac.uk/pdbsum/1tue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tue ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1tue]] is a 12 chain structure with sequence from [ | + | == Function == |
| + | [https://www.uniprot.org/uniprot/VE1_HPV18 VE1_HPV18] ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tu/1tue_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tue ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Helicase|Helicase]] | + | *[[Helicase 3D structures|Helicase 3D structures]] |
| - | + | *[[Regulatory protein E2|Regulatory protein E2]] | |
| - | + | *[[Replication protein E1|Replication protein E1]] | |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Human papillomavirus type 18]] | [[Category: Human papillomavirus type 18]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Abbate EA]] |
| - | [[Category: | + | [[Category: Berger JM]] |
| - | [[Category: | + | [[Category: Botchan MR]] |
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Current revision
The X-ray Structure of the Papillomavirus Helicase in Complex with its Molecular Matchmaker E2
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