1z1c
From Proteopedia
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| - | [[Image:1z1c.png|left|200px]] | ||
| - | + | ==Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute virus of Mice== | |
| - | + | <StructureSection load='1z1c' size='340' side='right'caption='[[1z1c]], [[Resolution|resolution]] 3.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1z1c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_minute_virus_(STRAIN_MVMI) Murine minute virus (STRAIN MVMI)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z1C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=D5M:2-DEOXYADENOSINE-5-MONOPHOSPHATE'>D5M</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z1c OCA], [https://pdbe.org/1z1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z1c RCSB], [https://www.ebi.ac.uk/pdbsum/1z1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z1c ProSAT]</span></td></tr> |
| - | [[1z1c]] is a 3 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CAPSD_MUMIM CAPSD_MUMIM] Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus (By similarity). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z1/1z1c_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z1c ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Virus coat | + | *[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | [[Category: | + | [[Category: Agbandje-McKenna M]] |
| - | [[Category: Agbandje-McKenna | + | [[Category: Almendral JM]] |
| - | [[Category: Almendral | + | [[Category: Bryant N]] |
| - | [[Category: Bryant | + | [[Category: Foces-Foces C]] |
| - | [[Category: Foces-Foces | + | [[Category: Govindasamy L]] |
| - | [[Category: Govindasamy | + | [[Category: Hernando E]] |
| - | [[Category: Hernando | + | [[Category: Kontou M]] |
| - | [[Category: Kontou | + | [[Category: Llamas-Saiz AL]] |
| - | [[Category: Llamas-Saiz | + | [[Category: McKenna R]] |
| - | [[Category: McKenna | + | [[Category: Nam HJ]] |
| - | [[Category: Nam | + | [[Category: Rubio MP]] |
| - | [[Category: Rubio | + | |
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Current revision
Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute virus of Mice
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