3rlr
From Proteopedia
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| - | [[Image:3rlr.png|left|200px]] | ||
| - | + | ==Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile== | |
| - | + | <StructureSection load='3rlr' size='340' side='right'caption='[[3rlr]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3rlr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RLR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3RR:4-(2,4-DICHLORO-5-METHOXYPHENYL)-2,6-DIMETHYL-7H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBONITRILE'>3RR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rlr OCA], [https://pdbe.org/3rlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rlr RCSB], [https://www.ebi.ac.uk/pdbsum/3rlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rlr ProSAT]</span></td></tr> |
| - | [[3rlr]] is a 2 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Heat Shock | + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bergqvist | + | [[Category: Large Structures]] |
| - | [[Category: Gajiwala | + | [[Category: Bergqvist S]] |
| - | [[Category: Hickey | + | [[Category: Gajiwala KS]] |
| - | [[Category: Huang | + | [[Category: Hickey MJ]] |
| - | [[Category: Kania | + | [[Category: Huang B]] |
| - | [[Category: Kung | + | [[Category: Kania R]] |
| - | [[Category: Maegley | + | [[Category: Kung P-P]] |
| - | [[Category: McClellan | + | [[Category: Maegley K]] |
| - | [[Category: Mehta | + | [[Category: McClellan G]] |
| - | [[Category: Richardson | + | [[Category: Mehta PP]] |
| - | [[Category: Sinnema | + | [[Category: Richardson P]] |
| - | [[Category: Wang | + | [[Category: Sinnema P-J]] |
| - | [[Category: Wang | + | [[Category: Wang F]] |
| - | + | [[Category: Wang J]] | |
Current revision
Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
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Categories: Homo sapiens | Large Structures | Bergqvist S | Gajiwala KS | Hickey MJ | Huang B | Kania R | Kung P-P | Maegley K | McClellan G | Mehta PP | Richardson P | Sinnema P-J | Wang F | Wang J
