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1p6n

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[[Image:1p6n.png|left|200px]]
 
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{{STRUCTURE_1p6n| PDB=1p6n | SCENE= }}
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==Bovine endothelial NOS heme domain with L-N(omega)-nitroarginine-(4R)-amino-L-proline amide bound==
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<StructureSection load='1p6n' size='340' side='right'caption='[[1p6n]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Bovine endothelial NOS heme domain with L-N(omega)-nitroarginine-(4R)-amino-L-proline amide bound===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1p6n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P6N FirstGlance]. <br>
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{{ABSTRACT_PUBMED_14718923}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=DP9:L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE+AMIDE'>DP9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6n OCA], [https://pdbe.org/1p6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p6n RCSB], [https://www.ebi.ac.uk/pdbsum/1p6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p6n ProSAT]</span></td></tr>
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[[1p6n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6N OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p6/1p6n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p6n ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Nitric Oxide Synthase|Nitric Oxide Synthase]]
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*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:014718923</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Nitric-oxide synthase]]
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[[Category: Large Structures]]
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[[Category: Flinspach, M L.]]
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[[Category: Flinspach ML]]
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[[Category: Gomez-Vidal, J A.]]
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[[Category: Gomez-Vidal JA]]
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[[Category: Hah, J M.]]
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[[Category: Hah J-M]]
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[[Category: Huang, H.]]
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[[Category: Huang H]]
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[[Category: Jamal, J.]]
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[[Category: Jamal J]]
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[[Category: Li, H.]]
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[[Category: Li H]]
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[[Category: Litzinger, E A.]]
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[[Category: Litzinger EA]]
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[[Category: Poulos, T L.]]
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[[Category: Poulos TL]]
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[[Category: Silverman, R B.]]
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[[Category: Silverman RB]]
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[[Category: Yang, W.]]
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[[Category: Yang W]]
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[[Category: Heme-enzyme]]
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[[Category: Nitric oxide synthase]]
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[[Category: Oxidoreductase]]
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Current revision

Bovine endothelial NOS heme domain with L-N(omega)-nitroarginine-(4R)-amino-L-proline amide bound

PDB ID 1p6n

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