3g5m

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[[Image:3g5m.png|left|200px]]
 
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{{STRUCTURE_3g5m| PDB=3g5m | SCENE= }}
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==Synthesis of Casimiroin and Optimization of Its Quinone Reductase 2 and Aromatase Inhibitory activity==
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<StructureSection load='3g5m' size='340' side='right'caption='[[3g5m]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3g5m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G5M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=XM5:6-METHOXY-9-METHYL[1,3]DIOXOLO[4,5-H]QUINOLIN-8(9H)-ONE'>XM5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5m OCA], [https://pdbe.org/3g5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g5m RCSB], [https://www.ebi.ac.uk/pdbsum/3g5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g5m ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/3g5m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g5m ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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An efficient method has been developed to synthesize casimiroin (1), a component of the edible fruit of Casimiroa edulis, on a multigram scale in good overall yield. The route was versatile enough to provide an array of compound 1 analogues that were evaluated as QR2 and aromatase inhibitors. In addition, X-ray crystallography studies of QR2 in complex with compound 1 and one of its more potent analogues has provided insight into the mechanism of action of this new series of QR2 inhibitors. The initial biological investigations suggest that compound 1 and its analogues merit further investigation as potential chemopreventive or chemotherapeutic agents.
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===Synthesis of Casimiroin and Optimization of Its Quinone Reductase 2 and Aromatase Inhibitory activity===
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Synthesis of Casimiroin and Optimization of Its Quinone Reductase 2 and Aromatase Inhibitory Activities.,Maiti A, Reddy PV, Sturdy M, Marler L, Pegan SD, Mesecar AD, Pezzuto JM, Cushman M J Med Chem. 2009 Mar 6. PMID:19265439<ref>PMID:19265439</ref>
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{{ABSTRACT_PUBMED_19265439}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3g5m" style="background-color:#fffaf0;"></div>
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[[3g5m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5M OCA].
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==See Also==
==See Also==
*[[Quinone reductase|Quinone reductase]]
*[[Quinone reductase|Quinone reductase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019265439</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cushman, M.]]
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[[Category: Large Structures]]
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[[Category: Maiti, A.]]
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[[Category: Cushman M]]
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[[Category: Marler, L.]]
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[[Category: Maiti A]]
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[[Category: Mesecar, A D.]]
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[[Category: Marler L]]
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[[Category: Pegan, S D.]]
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[[Category: Mesecar AD]]
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[[Category: Pezzuto, J M.]]
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[[Category: Pegan SD]]
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[[Category: Sturdy, M.]]
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[[Category: Pezzuto JM]]
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[[Category: Casimiroin]]
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[[Category: Sturdy M]]
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[[Category: Fad]]
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[[Category: Flavoprotein]]
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[[Category: Metal-binding]]
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[[Category: Nq02]]
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[[Category: Oxidoreductase]]
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[[Category: Phosphoprotein]]
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[[Category: Qr2]]
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Current revision

Synthesis of Casimiroin and Optimization of Its Quinone Reductase 2 and Aromatase Inhibitory activity

PDB ID 3g5m

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