1gp0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:23, 27 March 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1gp0.png|left|200px]]
 
-
{{STRUCTURE_1gp0| PDB=1gp0 | SCENE= }}
+
==Human IGF2R domain 11==
-
 
+
<StructureSection load='1gp0' size='340' side='right'caption='[[1gp0]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-
===HUMAN IGF2R DOMAIN 11===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1gp0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GP0 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_11867533}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gp0 OCA], [https://pdbe.org/1gp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gp0 RCSB], [https://www.ebi.ac.uk/pdbsum/1gp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gp0 ProSAT]</span></td></tr>
-
[[1gp0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GP0 OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MPRI_HUMAN MPRI_HUMAN] Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.<ref>PMID:10900005</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gp/1gp0_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gp0 ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
*[[Insulin-like growth factor receptor|Insulin-like growth factor receptor]]
*[[Insulin-like growth factor receptor|Insulin-like growth factor receptor]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:011867533</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Brown, J.]]
+
[[Category: Large Structures]]
-
[[Category: Esnouf, R M.]]
+
[[Category: Brown J]]
-
[[Category: Harlos, K.]]
+
[[Category: Esnouf RM]]
-
[[Category: Hassan, A B.]]
+
[[Category: Harlos K]]
-
[[Category: Jones, E Y.]]
+
[[Category: Hassan AB]]
-
[[Category: Jones, M A.]]
+
[[Category: Jones EY]]
-
[[Category: Linnell, J.]]
+
[[Category: Jones MA]]
-
[[Category: Beta barrel]]
+
[[Category: Linnell J]]
-
[[Category: Cation independent mannose 6-phosphate]]
+
-
[[Category: Insulin-like growth factor]]
+
-
[[Category: Receptor]]
+
-
[[Category: Transport]]
+

Current revision

Human IGF2R domain 11

PDB ID 1gp0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gp0"
Personal tools