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3og4

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[[Image:3og4.png|left|200px]]
 
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{{STRUCTURE_3og4| PDB=3og4 | SCENE= }}
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==The crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group P21212==
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<StructureSection load='3og4' size='340' side='right'caption='[[3og4]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3og4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OG4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3og4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3og4 OCA], [https://pdbe.org/3og4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3og4 RCSB], [https://www.ebi.ac.uk/pdbsum/3og4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3og4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IFNL1_HUMAN IFNL1_HUMAN] Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Interferon (IFN)-lambda1 [also known as interleukin (IL)-29] belongs to the recently discovered group of type III IFNs. All type III IFNs initiate signaling processes through formation of specific heterodimeric receptor complexes consisting of IFN-lambdaR1 and IL-10R2. We have determined the structure of human IFN-lambda1 complexed with human IFN-lambdaR1, a receptor unique to type III IFNs. The overall structure of IFN-lambda1 is topologically similar to the structure of IL-10 and other members of the IL-10 family of cytokines. IFN-lambdaR1 consists of two distinct domains having fibronectin type III topology. The ligand-receptor interface includes helix A, loop AB, and helix F on the IFN site, as well as loops primarily from the N-terminal domain and inter-domain hinge region of IFN-lambdaR1. Composition and architecture of the interface that includes only a few direct hydrogen bonds support an idea that long-range ionic interactions between ligand and receptor govern the process of initial recognition of the molecules while hydrophobic interactions finalize it.
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===The crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group P21212===
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Crystal Structure of Human Interferon-lambda1 in Complex with Its High-Affinity Receptor Interferon-lambdaR1.,Miknis Z, Magracheva E, Li W, Zdanov A, Kotenko SV, Wlodawer A J Mol Biol. 2010 Oct 8. PMID:20934432<ref>PMID:20934432</ref>
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{{ABSTRACT_PUBMED_20934432}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3og4" style="background-color:#fffaf0;"></div>
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[[3og4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OG4 OCA].
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==See Also==
==See Also==
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*[[Interferon|Interferon]]
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*[[Interferon 3D structures|Interferon 3D structures]]
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*[[Interleukin|Interleukin]]
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*[[Interferon receptor 3D structures|Interferon receptor 3D structures]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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==Reference==
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*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
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<ref group="xtra">PMID:020934432</ref><references group="xtra"/>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kotenko, S V.]]
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[[Category: Large Structures]]
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[[Category: Lei, W.]]
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[[Category: Kotenko SV]]
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[[Category: Magracheva, E.]]
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[[Category: Lei W]]
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[[Category: Miknis, Z J.]]
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[[Category: Magracheva E]]
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[[Category: Wlodawer, A.]]
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[[Category: Miknis ZJ]]
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[[Category: Zdanov, A.]]
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[[Category: Wlodawer A]]
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[[Category: Beta-sandwich]]
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[[Category: Zdanov A]]
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[[Category: Cytokine]]
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[[Category: Cytokine receptor]]
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[[Category: Cytokine-cytokine receptor complex]]
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[[Category: Fibronectin type iii domain]]
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[[Category: Helical bundle]]
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[[Category: Il-10r2]]
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[[Category: Membrane]]
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Current revision

The crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group P21212

PDB ID 3og4

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