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3to6

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[[Image:3to6.png|left|200px]]
 
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{{STRUCTURE_3to6| PDB=3to6 | SCENE= }}
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==Crystal structure of yeast Esa1 HAT domain complexed with H4K16CoA bisubstrate inhibitor==
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<StructureSection load='3to6' size='340' side='right'caption='[[3to6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Crystal structure of yeast Esa1 HAT domain complexed with H4K16CoA bisubstrate inhibitor===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3to6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TO6 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22020126}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=CMC:CARBOXYMETHYL+COENZYME+*A'>CMC</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3to6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3to6 OCA], [https://pdbe.org/3to6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3to6 RCSB], [https://www.ebi.ac.uk/pdbsum/3to6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3to6 ProSAT]</span></td></tr>
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[[3to6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TO6 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ESA1_YEAST ESA1_YEAST] Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, histone H2A to form H2AK4ac and H2AK7ac, and histone variant H2A.Z to form H2A.ZK14ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me.<ref>PMID:9858608</ref> <ref>PMID:10082517</ref> <ref>PMID:10835360</ref> <ref>PMID:10911987</ref> <ref>PMID:12353039</ref> <ref>PMID:15175650</ref> <ref>PMID:15494307</ref> <ref>PMID:15045029</ref> <ref>PMID:15923609</ref>
==See Also==
==See Also==
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*[[Histone acetyltransferase|Histone acetyltransferase]]
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*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022020126</ref><references group="xtra"/>
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__TOC__
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[[Category: Histone acetyltransferase]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Ding, E C.]]
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[[Category: Ding EC]]
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[[Category: Marmorstein, R.]]
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[[Category: Marmorstein R]]
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[[Category: Yuan, H.]]
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[[Category: Yuan H]]
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[[Category: Acetyltransferase]]
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[[Category: Autoacetylation]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal structure of yeast Esa1 HAT domain complexed with H4K16CoA bisubstrate inhibitor

PDB ID 3to6

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