This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1dg8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:53, 7 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1dg8.png|left|200px]]
 
-
{{STRUCTURE_1dg8| PDB=1dg8 | SCENE= }}
+
==DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH==
-
 
+
<StructureSection load='1dg8' size='340' side='right'caption='[[1dg8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
===DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1dg8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DG8 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_10623528}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dg8 OCA], [https://pdbe.org/1dg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dg8 RCSB], [https://www.ebi.ac.uk/pdbsum/1dg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dg8 ProSAT]</span></td></tr>
-
[[1dg8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DG8 OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dg/1dg8_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dg8 ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Dihydrofolate reductase|Dihydrofolate reductase]]
+
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:010623528</ref><ref group="xtra">PMID:016648861</ref><references group="xtra"/>
+
[[Category: Large Structures]]
-
[[Category: Dihydrofolate reductase]]
+
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
-
[[Category: Athappilly, F.]]
+
[[Category: Athappilly F]]
-
[[Category: Chitnumsub, P.]]
+
[[Category: Chitnumsub P]]
-
[[Category: Hol, W G.]]
+
[[Category: Hol WG]]
-
[[Category: Li, R.]]
+
[[Category: Li R]]
-
[[Category: Sirawaraporn, R.]]
+
[[Category: Sirawaraporn R]]
-
[[Category: Sirawaraporn, W.]]
+
[[Category: Sirawaraporn W]]
-
[[Category: Turley, S.]]
+
[[Category: Turley S]]
-
[[Category: Wooden, J.]]
+
[[Category: Wooden J]]
-
[[Category: Dihydrofolate reductase]]
+
-
[[Category: Folateanalog]]
+
-
[[Category: Nicotinamide adenine dinucleotide]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Rossmann fold]]
+
-
[[Category: Structure-based inhibitor design]]
+
-
[[Category: Tuberculosis]]
+

Current revision

DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH

PDB ID 1dg8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dg8"
Personal tools