This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1xdx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:06, 9 May 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1xdx.png|left|200px]]
 
-
{{STRUCTURE_1xdx| PDB=1xdx | SCENE= }}
+
==Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1==
 +
<StructureSection load='1xdx' size='340' side='right'caption='[[1xdx]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1xdx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XDX FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xdx OCA], [https://pdbe.org/1xdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xdx RCSB], [https://www.ebi.ac.uk/pdbsum/1xdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xdx ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/O64980_CHLRE O64980_CHLRE]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/1xdx_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xdx ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Tctex1 is a light chain found in both cytoplasmic and flagellar dyneins and is involved in many fundamental cellular activities, including rhodopsin transport within photoreceptors, and may function in the non-Mendelian transmission of t haplotypes in mice. Here, we present the NMR solution structure for the Tctex1 dimer from Chlamydomonas axonemal inner dynein arm I1. Structural comparisons reveal a strong similarity with the LC8 dynein light chain dimer, including formation of a strand-switched beta sheet interface. Analysis of the Tctex1 structure enables the dynein intermediate chain binding site to be identified and suggests a mechanism by which cargo proteins might be attached to this microtubule motor complex. Comparison with the alternate dynein light chain rp3 reveals how the specificity of dynein-cargo interactions mediated by these dynein components is achieved. In addition, this structure provides insight into the consequences of the mutations found in the t haplotype forms of this protein.
-
===Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1===
+
Solution structure of the Tctex1 dimer reveals a mechanism for dynein-cargo interactions.,Wu H, Maciejewski MW, Takebe S, King SM Structure. 2005 Feb;13(2):213-23. PMID:15698565<ref>PMID:15698565</ref>
-
{{ABSTRACT_PUBMED_15698565}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 1xdx" style="background-color:#fffaf0;"></div>
-
[[1xdx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDX OCA].
+
==See Also==
==See Also==
-
*[[Dynein|Dynein]]
+
*[[Dynein 3D structures|Dynein 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:015698565</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Chlamydomonas reinhardtii]]
[[Category: Chlamydomonas reinhardtii]]
-
[[Category: King, S M.]]
+
[[Category: Large Structures]]
-
[[Category: Maciejewski, M W.]]
+
[[Category: King SM]]
-
[[Category: Takebe, S.]]
+
[[Category: Maciejewski MW]]
-
[[Category: Wu, H.]]
+
[[Category: Takebe S]]
-
[[Category: Chlamydomonas flagella]]
+
[[Category: Wu H]]
-
[[Category: Contractile protein]]
+
-
[[Category: Nmr solution structure]]
+
-
[[Category: Tctex1 dimer]]
+

Current revision

Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1

PDB ID 1xdx

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xdx"
Personal tools