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3c7n

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[[Image:3c7n.png|left|200px]]
 
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{{STRUCTURE_3c7n| PDB=3c7n | SCENE= }}
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==Structure of the Hsp110:Hsc70 Nucleotide Exchange Complex==
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<StructureSection load='3c7n' size='340' side='right'caption='[[3c7n]], [[Resolution|resolution]] 3.12&Aring;' scene=''>
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===Structure of the Hsp110:Hsc70 Nucleotide Exchange Complex===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3c7n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C7N FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18550409}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.115&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c7n OCA], [https://pdbe.org/3c7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c7n RCSB], [https://www.ebi.ac.uk/pdbsum/3c7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c7n ProSAT]</span></td></tr>
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[[3c7n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C7N OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HSP7F_YEAST HSP7F_YEAST] Has a calcium-dependent calmodulin-binding activity. Required for normal growth at various temperatures.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/3c7n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c7n ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
*[[Heat Shock Proteins|Heat Shock Proteins]]
*[[Heat Shock Proteins|Heat Shock Proteins]]
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*[[Journal:JBSD:30|Journal:JBSD:30]]
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:018550409</ref><ref group="xtra">doi 10.1080/07391102.2012.726190</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Hart, P J.]]
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[[Category: Hart PJ]]
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[[Category: Jiang, J.]]
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[[Category: Jiang J]]
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[[Category: Schuermann, J P.]]
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[[Category: Schuermann JP]]
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[[Category: Sousa, R.]]
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[[Category: Sousa R]]
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[[Category: Adp]]
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[[Category: Atp state]]
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[[Category: Atp-binding]]
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[[Category: Calmodulin binding]]
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[[Category: Calmodulin-binding]]
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[[Category: Chaperone]]
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[[Category: Chaperone-chaperone complex]]
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[[Category: Hsc70]]
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[[Category: Hsp110]]
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[[Category: Hsp70]]
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[[Category: Molecular chaperone]]
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[[Category: Mucleotide binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Phosphorylation]]
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[[Category: Stress response]]
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[[Category: Transcription]]
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Current revision

Structure of the Hsp110:Hsc70 Nucleotide Exchange Complex

PDB ID 3c7n

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