2vl9

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[[Image:2vl9.png|left|200px]]
 
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{{STRUCTURE_2vl9| PDB=2vl9 | SCENE= }}
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==Oxidized form of human peroxiredoxin 5==
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<StructureSection load='2vl9' size='340' side='right'caption='[[2vl9]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2vl9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VL9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vl9 OCA], [https://pdbe.org/2vl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vl9 RCSB], [https://www.ebi.ac.uk/pdbsum/2vl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vl9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRDX5_HUMAN PRDX5_HUMAN] Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vl/2vl9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vl9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Peroxiredoxin 5 (PRDX5) belongs to the PRDX superfamily of thiol-dependent peroxidases able to reduce hydrogen peroxide, alkyl hydroperoxides and peroxynitrite. PRDX5 is classified in the atypical 2-Cys subfamily of PRDXs. In this subfamily, the oxidized form of the enzyme is characterized by the presence of an intramolecular disulfide bridge between the peroxidatic and the resolving cysteine residues. We report here three crystal forms in which this intramolecular disulfide bond is indeed observed. The structures are characterized by the expected local unfolding of the peroxidatic loop, but also by the unfolding of the resolving loop. A new type of interface between PRDX molecules is described. The three crystal forms were not oxidized in the same way and the influence of the oxidizing conditions is discussed.
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===OXIDIZED FORM OF HUMAN PEROXIREDOXIN 5===
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The crystal structures of oxidized forms of human peroxiredoxin 5 with an intramolecular disulfide bond confirm the proposed enzymatic mechanism for atypical 2-Cys peroxiredoxins.,Smeets A, Marchand C, Linard D, Knoops B, Declercq JP Arch Biochem Biophys. 2008 Sep 1;477(1):98-104. Epub 2008 May 4. PMID:18489898<ref>PMID:18489898</ref>
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{{ABSTRACT_PUBMED_18489898}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2vl9" style="background-color:#fffaf0;"></div>
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[[2vl9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL9 OCA].
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==See Also==
==See Also==
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*[[Peroxiredoxin|Peroxiredoxin]]
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*[[Peroxiredoxin 3D structures|Peroxiredoxin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018489898</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peroxiredoxin]]
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[[Category: Large Structures]]
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[[Category: Declercq, J P.]]
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[[Category: Declercq JP]]
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[[Category: Smeets, A.]]
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[[Category: Smeets A]]
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[[Category: Alternative initiation]]
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[[Category: Antioxidant]]
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[[Category: Antioxidant enzyme]]
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[[Category: Mitochondrion]]
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[[Category: Oxidoreductase]]
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[[Category: Peroxidase]]
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[[Category: Peroxiredoxin]]
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[[Category: Peroxisome]]
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[[Category: Redox-active center]]
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[[Category: Thioredoxin fold]]
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[[Category: Thioredoxin peroxidase]]
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[[Category: Transit peptide]]
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Current revision

Oxidized form of human peroxiredoxin 5

PDB ID 2vl9

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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