1p44

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[[Image:1p44.png|left|200px]]
 
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{{STRUCTURE_1p44| PDB=1p44 | SCENE= }}
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==Targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural data==
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<StructureSection load='1p44' size='340' side='right'caption='[[1p44]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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===Targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural data===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1p44]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P44 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12606558}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GEQ:5-{[4-(9H-FLUOREN-9-YL)PIPERAZIN-1-YL]CARBONYL}-1H-INDOLE'>GEQ</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p44 OCA], [https://pdbe.org/1p44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p44 RCSB], [https://www.ebi.ac.uk/pdbsum/1p44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p44 ProSAT], [https://www.topsan.org/Proteins/TBSGC/1p44 TOPSAN]</span></td></tr>
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[[1p44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P44 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/INHA_MYCTU INHA_MYCTU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p4/1p44_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p44 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Enoyl-Acyl-Carrier Protein Reductase|Enoyl-Acyl-Carrier Protein Reductase]]
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*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:012606558</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Alland, D.]]
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[[Category: Alland D]]
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[[Category: Fidock, D A.]]
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[[Category: Fidock DA]]
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[[Category: Gourlie, B B.]]
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[[Category: Gourlie BB]]
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[[Category: Gregory, J S.]]
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[[Category: Gregory JS]]
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[[Category: Iwamoto, H.]]
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[[Category: Iwamoto H]]
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[[Category: Janjigian, A D.]]
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[[Category: Jacobs Jr WR]]
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[[Category: Jr, W R.Jacobs.]]
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[[Category: Janjigian AD]]
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[[Category: Kreiswirth, B.]]
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[[Category: Kreiswirth B]]
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[[Category: Kuo, M R.]]
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[[Category: Kuo MR]]
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[[Category: Leonard, M.]]
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[[Category: Leonard M]]
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[[Category: Morbidoni, H R.]]
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[[Category: Morbidoni HR]]
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[[Category: Musser, J M.]]
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[[Category: Musser JM]]
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[[Category: Perozzo, R.]]
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[[Category: Perozzo R]]
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[[Category: Sacchettini, J C.]]
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[[Category: Sacchettini JC]]
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[[Category: Sneddon, S F.]]
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[[Category: Sneddon SF]]
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[[Category: Staveski, M M.]]
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[[Category: Staveski MM]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Yee C]]
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[[Category: Yee, C.]]
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[[Category: Enoyl-acp reductase]]
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[[Category: Inha]]
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[[Category: Inhibitor]]
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[[Category: Oxidoreductase]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Rossmann fold]]
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[[Category: Short chain dehydrogenase reductase]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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Current revision

Targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural data

PDB ID 1p44

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