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3lep

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[[Image:3lep.png|left|200px]]
 
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{{STRUCTURE_3lep| PDB=3lep | SCENE= }}
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==Human Aldose Reductase mutant T113C in complex with IDD388==
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<StructureSection load='3lep' size='340' side='right'caption='[[3lep]], [[Resolution|resolution]] 0.99&Aring;' scene=''>
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===Human Aldose Reductase mutant T113C in complex with IDD388===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3lep]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LEP FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21185307}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.99&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=388:(2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC+ACID'>388</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lep OCA], [https://pdbe.org/3lep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lep RCSB], [https://www.ebi.ac.uk/pdbsum/3lep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lep ProSAT]</span></td></tr>
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[[3lep]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEP OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
==See Also==
==See Also==
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*[[Aldose Reductase|Aldose Reductase]]
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*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:021185307</ref><references group="xtra"/>
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[[Category: Aldehyde reductase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Heine, A.]]
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[[Category: Large Structures]]
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[[Category: Klebe, G.]]
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[[Category: Heine A]]
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[[Category: Koch, C.]]
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[[Category: Klebe G]]
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[[Category: Nadp]]
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[[Category: Koch C]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Phosphoprotein]]
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[[Category: T113c mutant]]
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[[Category: Tim barrel]]
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Current revision

Human Aldose Reductase mutant T113C in complex with IDD388

PDB ID 3lep

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