4lbd

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[[Image:4lbd.png|left|200px]]
 
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{{STRUCTURE_4lbd| PDB=4lbd | SCENE= }}
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==LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO THE SYNTHETIC AGONIST BMS961==
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<StructureSection load='4lbd' size='340' side='right'caption='[[4lbd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO THE SYNTHETIC AGONIST BMS961===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4lbd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LBD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=961:3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC+ACID'>961</scene></td></tr>
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[[4lbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LBD OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lbd OCA], [https://pdbe.org/4lbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lbd RCSB], [https://www.ebi.ac.uk/pdbsum/4lbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lbd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RARG_HUMAN RARG_HUMAN] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lb/4lbd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4lbd ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Retinoic acid receptor|Retinoic acid receptor]]
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*[[Retinoic acid receptor 3D structures|Retinoic acid receptor 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:009501913</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Klaholz, B P.]]
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[[Category: Large Structures]]
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[[Category: Mitschler, A.]]
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[[Category: Klaholz BP]]
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[[Category: Moras, D.]]
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[[Category: Mitschler A]]
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[[Category: Renaud, J P.]]
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[[Category: Moras D]]
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[[Category: SPINE, Structural Proteomics in Europe.]]
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[[Category: Renaud J-P]]
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[[Category: Active conformation]]
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[[Category: All-trans retinoic acid]]
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[[Category: Complex]]
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[[Category: Holo form]]
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[[Category: Ligand-binding domain]]
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[[Category: Ligand-dependent]]
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[[Category: Nuclear receptor]]
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[[Category: Retinoic acid receptor]]
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[[Category: Spine]]
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[[Category: Structural genomic]]
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[[Category: Structural proteomics in europe]]
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[[Category: Transcription regulation]]
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Current revision

LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO THE SYNTHETIC AGONIST BMS961

PDB ID 4lbd

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