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3srs

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[[Image:3srs.png|left|200px]]
 
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{{STRUCTURE_3srs| PDB=3srs | SCENE= }}
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==S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines==
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<StructureSection load='3srs' size='340' side='right'caption='[[3srs]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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===S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3srs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SRS FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21831637}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M23:7-(5-BROMO-2-ETHOXYPHENYL)-6-METHYLQUINAZOLINE-2,4-DIAMINE'>M23</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3srs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3srs OCA], [https://pdbe.org/3srs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3srs RCSB], [https://www.ebi.ac.uk/pdbsum/3srs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3srs ProSAT]</span></td></tr>
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[[3srs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SRS OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
==See Also==
==See Also==
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*[[Dihydrofolate reductase|Dihydrofolate reductase]]
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:021831637</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Dihydrofolate reductase]]
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[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Hilgers, M.]]
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[[Category: Hilgers M]]
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[[Category: Dhfr]]
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[[Category: Dihydrofolate reductase]]
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[[Category: Drug design]]
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[[Category: Enzyme inhibitor]]
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[[Category: Folate]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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Current revision

S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines

PDB ID 3srs

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