3ig3

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[[Image:3ig3.png|left|200px]]
 
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{{STRUCTURE_3ig3| PDB=3ig3 | SCENE= }}
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==Crystal structure of mouse Plexin A3 intracellular domain==
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<StructureSection load='3ig3' size='340' side='right'caption='[[3ig3]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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===Crystal strucure of mouse Plexin A3 intracellular domain===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ig3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IG3 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19717441}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ig3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ig3 OCA], [https://pdbe.org/3ig3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ig3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ig3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ig3 ProSAT]</span></td></tr>
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[[3ig3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IG3 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PLXA3_MOUSE PLXA3_MOUSE] Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.<ref>PMID:11683995</ref> <ref>PMID:18262512</ref> <ref>PMID:18804103</ref> <ref>PMID:19020035</ref> <ref>PMID:19717441</ref> <ref>PMID:20010807</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ig/3ig3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ig3 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Plexin|Plexin]]
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*[[Plexin 3D structures|Plexin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019717441</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: He, H.]]
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[[Category: He H]]
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[[Category: Zhang, X.]]
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[[Category: Zhang X]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Plexin intracellular gap rbd inactive]]
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[[Category: Signaling protein]]
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[[Category: Transmembrane]]
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Current revision

Crystal structure of mouse Plexin A3 intracellular domain

PDB ID 3ig3

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