1bg7

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[[Image:1bg7.png|left|200px]]
 
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{{STRUCTURE_1bg7| PDB=1bg7 | SCENE= }}
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==LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?==
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<StructureSection load='1bg7' size='340' side='right'caption='[[1bg7]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bg7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lithobates_catesbeianus Lithobates catesbeianus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BG7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bg7 OCA], [https://pdbe.org/1bg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bg7 RCSB], [https://www.ebi.ac.uk/pdbsum/1bg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bg7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FRI1_LITCT FRI1_LITCT] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.<ref>PMID:9668036</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/1bg7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bg7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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How and where iron exits from ferritin for cellular use is unknown. Twenty-four protein subunits create a cavity in ferritin where iron is concentrated &gt;10(11)-fold as a mineral. Proline substitution for conserved leucine 134 (L134P) allowed normal assembly but increased iron exit rates. X-ray crystallography of H-L134P ferritin revealed localized unfolding at the 3-fold axis, also iron entry sites, consistent with shared use sites for iron exit and entry. The junction of three ferritin subunits appears to be a dynamic aperture with a "shutter" that cytoplasmic factors might open or close to regulate iron release in vivo.
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===LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?===
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Localized unfolding at the junction of three ferritin subunits. A mechanism for iron release?,Takagi H, Shi D, Ha Y, Allewell NM, Theil EC J Biol Chem. 1998 Jul 24;273(30):18685-8. PMID:9668036<ref>PMID:9668036</ref>
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{{ABSTRACT_PUBMED_9668036}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1bg7" style="background-color:#fffaf0;"></div>
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[[1bg7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rana_catesbeiana Rana catesbeiana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BG7 OCA].
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==See Also==
==See Also==
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*[[Ferritin|Ferritin]]
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*[[Ferritin 3D structures|Ferritin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:009668036</ref><references group="xtra"/>
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__TOC__
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[[Category: Rana catesbeiana]]
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</StructureSection>
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[[Category: Allewell, N M.]]
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[[Category: Large Structures]]
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[[Category: Ha, Y.]]
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[[Category: Lithobates catesbeianus]]
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[[Category: Shi, D.]]
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[[Category: Allewell NM]]
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[[Category: Takagi, H.]]
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[[Category: Ha Y]]
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[[Category: Theil, E C.]]
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[[Category: Shi D]]
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[[Category: Ferritin]]
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[[Category: Takagi H]]
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[[Category: Iron storage]]
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[[Category: Theil EC]]

Current revision

LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?

PDB ID 1bg7

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