1nzs

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[[Image:1nzs.png|left|200px]]
 
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{{STRUCTURE_1nzs| PDB=1nzs | SCENE= }}
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==NMR structures of phosphorylated carboxy terminus of bovine rhodopsin in arrestin-bound state==
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<StructureSection load='1nzs' size='340' side='right'caption='[[1nzs]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nzs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NZS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nzs OCA], [https://pdbe.org/1nzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nzs RCSB], [https://www.ebi.ac.uk/pdbsum/1nzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nzs ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Visual arrestin binds to the phosphorylated carboxy-terminal region of rhodopsin to block interactions with transducin and terminate signaling in the rod photoreceptor cells. A synthetic seven-phospho-peptide from the C-terminal region of rhodopsin, Rh(330-348), has been shown to bind arrestin and mimic inhibition of signal transduction. In this study, we examine conformational changes in this synthetic peptide upon binding to arrestin by high-resolution proton nuclear magnetic resonance (NMR). We show that the peptide is completely disordered in solution, but becomes structured upon binding to arrestin. A control, unphosphorylated peptide that fails to bind to arrestin remains highly disordered. Specific NMR distance constraints are used to model the arrestin-bound conformation. The models suggest that the phosphorylated carboxy-terminal region of rhodopsin, Rh(330-348), undergoes significant conformational changes and becomes structured upon binding to arrestin.
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===NMR structures of phosphorylated carboxy terminus of bovine rhodopsin in arrestin-bound state===
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The arrestin-bound conformation and dynamics of the phosphorylated carboxy-terminal region of rhodopsin.,Kisselev OG, McDowell JH, Hargrave PA FEBS Lett. 2004 Apr 30;564(3):307-11. PMID:15111114<ref>PMID:15111114</ref>
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{{ABSTRACT_PUBMED_15111114}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1nzs" style="background-color:#fffaf0;"></div>
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[[1nzs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZS OCA].
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==See Also==
==See Also==
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*[[Rhodopsin|Rhodopsin]]
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*[[Rhodopsin 3D structures|Rhodopsin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015111114</ref><references group="xtra"/>
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__TOC__
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[[Category: Hargrave, P A.]]
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</StructureSection>
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[[Category: Kisselev, O G.]]
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[[Category: Bos taurus]]
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[[Category: McDowell, J H.]]
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[[Category: Large Structures]]
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[[Category: Arrestin]]
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[[Category: Hargrave PA]]
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[[Category: Ball-and-chain]]
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[[Category: Kisselev OG]]
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[[Category: Bound conformation]]
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[[Category: McDowell JH]]
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[[Category: Gpcr]]
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[[Category: Helix-loop]]
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[[Category: Phosphorylation]]
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[[Category: Rhodopsin]]
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[[Category: Signal termination]]
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[[Category: Signaling protein]]
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Current revision

NMR structures of phosphorylated carboxy terminus of bovine rhodopsin in arrestin-bound state

PDB ID 1nzs

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